MedKoo Cat#: 564751 | Name: IPTBC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IPTBC is an inhibitor of the antiapoptotic Bcl-2 protein by acting as a BH3 mimetic. IPTBC exhibits dose-dependent cytotoxicity in breast adenocarcinoma (MCF-7) cells.

Chemical Structure

IPTBC
IPTBC
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564751

Name: IPTBC

CAS#: NONE

Chemical Formula: C24H19BrN4O2S

Exact Mass: 506.0412

Molecular Weight: 507.41

Elemental Analysis: C, 56.81; H, 3.77; Br, 15.75; N, 11.04; O, 6.31; S, 6.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
IPTBC
IUPAC/Chemical Name
3-(1-(5-(3-(1H-Indol-3-yl)propyl)-1,3,4-thiadiazol-2-ylimino)ethyl)-6-bromo-2H-chromen-2-one
InChi Key
KOYPXDNDAUYBKR-MZJWZYIUSA-N
InChi Code
InChI=1S/C24H19BrN4O2S/c1-14(19-12-16-11-17(25)9-10-21(16)31-23(19)30)27-24-29-28-22(32-24)8-4-5-15-13-26-20-7-3-2-6-18(15)20/h2-3,6-7,9-13,26H,4-5,8H2,1H3/b27-14+
SMILES Code
O=C1C(/C(C)=N/C2=NN=C(CCCC3=CNC4=C3C=CC=C4)S2)=CC5=C(O1)C=CC(Br)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 507.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kamath PR, Sunil D, Joseph MM, Abdul Salam AA, T T S. Indole-coumarin-thiadiazole hybrids: An appraisal of their MCF-7 cell growth inhibition, apoptotic, antimetastatic and computational Bcl-2 binding potential. Eur J Med Chem. 2017 Aug 18;136:442-451. doi: 10.1016/j.ejmech.2017.05.032. Epub 2017 May 11. PubMed PMID: 28525842.