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MedKoo Cat#: 564746 | Name: PPA250

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPA250 is an iNOS homodimerization inhibitor.

Chemical Structure

PPA250
PPA250
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564746

Name: PPA250

CAS#: NONE

Chemical Formula: C29H23F2N3O2

Exact Mass: 483.1758

Molecular Weight: 483.52

Elemental Analysis: C, 72.04; H, 4.79; F, 7.86; N, 8.69; O, 6.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PPA-250; PPA 250; PPA250
IUPAC/Chemical Name
6-(2-(4-((1H-Imidazol-1-yl)methyl)phenoxy)ethoxy)-3-(2,4-difluorophenyl)-2-phenylpyridine
InChi Key
BMSLEFJNHPVCLR-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H23F2N3O2/c30-23-8-11-25(27(31)18-23)26-12-13-28(33-29(26)22-4-2-1-3-5-22)36-17-16-35-24-9-6-21(7-10-24)19-34-15-14-32-20-34/h1-15,18,20H,16-17,19H2
SMILES Code
FC1=CC=C(C2=CC=C(OCCOC3=CC=C(CN4C=CN=C4)C=C3)N=C2C5=CC=CC=C5)C(F)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 483.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ohtsuka M, Konno F, Honda H, Oikawa T, Ishikawa M, Iwase N, Isomae K, Ishii F, Hemmi H, Sato S. PPA250 [3-(2,4-difluorophenyl)-6-[2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy]-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis. J Pharmacol Exp Ther. 2002 Oct;303(1):52-7. PubMed PMID: 12235232.