MedKoo Cat#: 573280 | Name: Artemisinin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases.

Chemical Structure

Artemisinin B
CAS#145941-07-7

Theoretical Analysis

MedKoo Cat#: 573280

Name: Artemisinin B

CAS#: 145941-07-7

Chemical Formula: C15H22O4

Exact Mass: 266.1518

Molecular Weight: 266.34

Elemental Analysis: C, 67.65; H, 8.33; O, 24.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Artemisinin B
IUPAC/Chemical Name
1-Naphthaleneacetic acid, 1,2,3,4,4a,5,8,8a-octahydro-8,8a-dihydroxy-4,7-dimethyl-alpha-methylene-, (1S-(1alpha,4beta,4abeta,8beta,8abeta))-
InChi Key
PVBSTLWHHZPUSK-JDRMZHCHSA-N
InChi Code
1S/C15H22O4/c1-8-4-7-12(10(3)14(17)18)15(19)11(8)6-5-9(2)13(15)16/h5,8,11-13,16,19H,3-4,6-7H2,1-2H3,(H,17,18)/t8-,11+,12+,13-,15-/m1/s1
SMILES Code
C1C[C@@H](C)[C@H]2[C@](O)([C@@H]1C(=C)C(O)=O)[C@@H](C(=CC2)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 266.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qiang W, Cai W, Yang Q, Yang L, Dai Y, Zhao Z, Yin J, Li Y, Li Q, Wang Y, Weng X, Zhang D, Chen Y, Zhu X. Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation. Neuroscience. 2018 Dec 15;395:1-12. doi: 10.1016/j.neuroscience.2018.10.041. Epub 2018 Nov 3. PubMed PMID: 30399421. 2: Sun WC, Han JX, Yang WY, Deng DA, Yue XF. [Antitumor activities of 4 derivatives of artemisic acid and artemisinin B in vitro]. Zhongguo Yao Li Xue Bao. 1992 Nov;13(6):541-3. Chinese. Erratum in: Chung Kuo Yao Li Hsueh Pao 1993 Mar;14(2):192. PubMed PMID: 1302444.