IUPAC/Chemical Name
3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
InChi Key
SXYIRMFQILZOAM-CNNNLJIRSA-N
InChi Code
1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,14-,15-,16-/m1/s1
SMILES Code
O1[C@H]([C@@H]([C@@H]2CC[C@H](C)[C@@H]3CC[C@@]4(O[C@H]1[C@@]23OO4)C)C)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
298.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tian L, Liu J, Jia Q, Ying Y, Yang Z, Huang G. Preparation and Evaluation of Artemether Liposomes for Enhanced Anti-Tumor Therapy. AAPS PharmSciTech. 2018 Feb;19(2):512-521. doi: 10.1208/s12249-017-0896-9. Epub 2017 Oct 16. PubMed PMID: 29038986.
2: Abd El-Aal NF, Hamza RS, Magdy M. Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in experimental mansoniasis. Acta Parasitol. 2017 Dec 20;62(4):708-716. doi: 10.1515/ap-2017-0085. PubMed PMID: 29035850.
3: Tan WQ, Chen G, Ye M, Jia B. Artemether Regulates Chemosensitivity to Doxorubicin via Regulation of B7-H3 in Human Neuroblastoma Cells. Med Sci Monit. 2017 Sep 3;23:4252-4259. PubMed PMID: 28866709; PubMed Central PMCID: PMC5594998.
4: Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL, Olajide OA. Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms. Mol Neurobiol. 2016 Nov;53(9):6426-6443. doi: 10.1007/s12035-015-9543-1. Epub 2015 Nov 25. PubMed PMID: 26607631.
5: Esu E, Effa EE, Opie ON, Uwaoma A, Meremikwu MM. Artemether for severe malaria. Cochrane Database Syst Rev. 2014 Sep 11;(9):CD010678. doi: 10.1002/14651858.CD010678.pub2. Review. PubMed PMID: 25209020; PubMed Central PMCID: PMC4455227.
