Artonin E | CAS# 129683-93-8 | Anti-tumor

MedKoo Cat#: 573275 | Name: Artonin E

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Artonin E is an anti-tumor drug which has been shown to induce p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells. Artonin E may also be effective in treatment of MDA-MB 231 triple negative breast cancer.

Chemical Structure

Artonin E

CAS#129683-93-8

Theoretical Analysis

MedKoo Cat#: 573275

Name: Artonin E

CAS#: 129683-93-8

Chemical Formula: C25H24O7

Exact Mass: 436.1522

Molecular Weight: 436.46

Elemental Analysis: C, 68.80; H, 5.54; O, 25.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

5'-Hydroxymorusin, Artonin E

IUPAC/Chemical Name

4H,8H-Benzo(1,2-b:3,4-b')dipyran-4-one, 5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-2-(2,4,5-trihydroxyphenyl)-

InChi Key

HDHRTQZSBFUBMJ-UHFFFAOYSA-N

InChi Code

1S/C25H24O7/c1-12(2)5-6-14-22(30)21-19(29)11-20-13(7-8-25(3,4)32-20)24(21)31-23(14)15-9-17(27)18(28)10-16(15)26/h5,7-11,26-29H,6H2,1-4H3

SMILES Code

CC(=CCc1c(=O)c2c(cc3c(c2oc1c4cc(c(cc4O)O)O)C=CC(O3)(C)C)O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 436.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Etti IC, Abdullah R, Kadir A, Hashim NM, Yeap SK, Imam MU, Ramli F, Malami I, Lam KL, Etti U, Waziri P, Rahman M. The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells. PLoS One. 2017 Aug 3;12(8):e0182357. doi: 10.1371/journal.pone.0182357. eCollection 2017. PubMed PMID: 28771532; PubMed Central PMCID: PMC5542509. 2: Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ. Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells. Drug Des Devel Ther. 2017 Mar 20;11:865-879. doi: 10.2147/DDDT.S124324. eCollection 2017. PubMed PMID: 28356713; PubMed Central PMCID: PMC5367776. 3: Etti I, Abdullah R, Hashim NM, Kadir A, Abdul AB, Etti C, Malami I, Waziri P, How CW. Artonin E and Structural Analogs from Artocarpus Species Abrogates Estrogen Receptor Signaling in Breast Cancer. Molecules. 2016 Jun 29;21(7). pii: E839. doi: 10.3390/molecules21070839. PubMed PMID: 27367662; PubMed Central PMCID: PMC6272880. 4: Rahman MA, Ramli F, Karimian H, Dehghan F, Nordin N, Ali HM, Mohan S, Hashim NM. Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells. PLoS One. 2016 Mar 28;11(3):e0151466. doi: 10.1371/journal.pone.0151466. eCollection 2016. PubMed PMID: 27019365; PubMed Central PMCID: PMC4809498.