MedKoo Cat#: 564731 | Name: NHNB

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NHNB is a selective inhibitor of histone deacetylases-8 (HDAC8). NHNB provides the most potent CE4 inhibitor reported to date.

Chemical Structure

NHNB
CAS#106359-61-9

Theoretical Analysis

MedKoo Cat#: 564731

Name: NHNB

CAS#: 106359-61-9

Chemical Formula: C17H13NO2

Exact Mass: 263.0946

Molecular Weight: 263.30

Elemental Analysis: C, 77.55; H, 4.98; N, 5.32; O, 12.15

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Synonym
NHNB
IUPAC/Chemical Name
N-Hydroxy-4-(naphthalene-1-yl)benzamide
InChi Key
PKQVYJOPUCLLCD-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13NO2/c19-17(18-20)14-10-8-13(9-11-14)16-7-3-5-12-4-1-2-6-15(12)16/h1-11,20H,(H,18,19)
SMILES Code
O=C(NO)C1=CC=C(C2=C3C=CC=CC3=CC=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Balomenou S, Koutsioulis D, Tomatsidou A, Tzanodaskalaki M, Petratos K, Bouriotis V. Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus. Bioorg Med Chem. 2018 Jul 30;26(13):3845-3851. doi: 10.1016/j.bmc.2018.06.045. Epub 2018 Jul 4. PubMed PMID: 29983281.