Synonym
MT 0703; Antibiotic MT 0703; MT0703
IUPAC/Chemical Name
Pyridinium, 4-(((7-(((2-amino-4-thiazolyl)(((1,4-dihydro-1,5-dihydroxy-1,5-dihydroxy-4-oxo-2-pyridinyl)carbonyl)amino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)thio)-1-(2-hydroxyethyl)-, hydroxide, inner salt, (6R-(6alpha,7beta))-
InChi Key
FQRIHMKPNWMVCQ-ZAZMHIJSSA-N
InChi Code
InChI=1S/C26H28N7O11S3/c27-25-28-14(10-47-25)17(29-20(36)15-7-16(35)26(41,42)11-33(15,43)44)21(37)30-18-22(38)32-19(24(39)40)12(9-46-23(18)32)8-45-13-1-3-31(4-2-13)5-6-34/h1-4,7,10,17-18,23,34,41-44H,5-6,8-9,11H2,(H4-,27,28,29,30,36,37,39,40)/t17?,18-,23-/m1/s1
SMILES Code
OCC[N+]1=CC=C(SCC(CS[C@]2([H])[C@@H]3NC(C(C4=CSC(N)=N4)NC(C5=CC(C(O)(O)C[N]5(O)O)=O)=O)=O)=C(C([O-])=O)N2C3=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
710.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Holihan JL, Chen JS, Greenberg J, Hehir D, Johnston SM, Marcus D, Ryan H, Tsuda S, Liang MK. Incidence of Port-Site Hernias: A Survey and Literature Review. Surg Laparosc Endosc Percutan Tech. 2016 Dec;26(6):425-430. Review. PubMed PMID: 27846177.
2: Numata G, Amiya E, Kojima T, Fujiu K, Hatano M, Watanabe M, Komuro I. Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly. Int Heart J. 2017 Oct 21;58(5):816-819. doi: 10.1536/ihj.16-580. Epub 2017 Sep 30. PubMed PMID: 28966329.
3: Ogino H, Iwamatsu K, Katano K, Nakabayashi S, Yoshida T, Tsuruoka T, Inouye S, Kondo S. New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. I. Synthesis and biological activity of cephalosporin derivatives leading to MT0703. J Antibiot (Tokyo). 1990 Feb;43(2):174-88. PubMed PMID: 2179185.
4: Pittman M, Sakai L, Craig R, Joehl R, Milner R. Primary aortoenteric fistula following disseminated bacillus Calmette-Guérin infection: a case report. Vascular. 2012 Aug;20(4):221-4. doi: 10.1258/vasc.2011.cr0315. Epub 2012 Aug 7. Review. PubMed PMID: 22871545.
5: Okamoto R, Hara T, Yoshida T, Orikasa Y, Ogino H, Iwamatsu K, Inouye S. In vitro antimicrobial activity of a novel aminothiazolylglycylcephalosporin, MT0703S, compared with that of ceftazidime, cefoperazone and aztreonam. Drugs Exp Clin Res. 1990;16(4):157-65. PubMed PMID: 2127567.
6: Ogino H, Iwamatsu K, Katano K, Nakabayashi S, Yoshida T, Shibahara S, Tsuruoka T, Inouye S, Kondo S. New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. II. Synthesis and antibacterial activity of MT0703 and its diastereomers. J Antibiot (Tokyo). 1990 Feb;43(2):189-98. PubMed PMID: 2179186.
