NPC 17731 | CAS# 147267-10-5 | Bradykinin Receptor Antagonist

MedKoo Cat#: 573265 | Name: NPC 17731

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPC 17731 is a bradykinin receptor antagonist.

Chemical Structure

NPC 17731

CAS#147267-10-5

Theoretical Analysis

MedKoo Cat#: 573265

Name: NPC 17731

CAS#: 147267-10-5

Chemical Formula: C59H95N19O14

Exact Mass: 1293.7306

Molecular Weight: 1294.53

Elemental Analysis: C, 54.74; H, 7.40; N, 20.56; O, 17.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NPC 17731

IUPAC/Chemical Name

(4S)-2-(1-((S)-1-(D-arginyl-L-arginyl)pyrrolidin-2-yl)-4-guanidino-1-oxobutan-2-yl)-5-hydroxy-4-((2S)-2-(2-((2S)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-oxo-2-((3aS,7aS)-N-((2R,4S)-4-propoxypyrrolidine-2-carbonyl)octahydro-1H-indole-2-carboxamido)pentanoic acid

InChi Key

WYWZCALINPVKJW-KOCZGPIPSA-N

InChi Code

1S/C59H95N19O14/c1-2-23-92-35-27-42(71-29-35)53(88)78(54(89)43-25-33-13-6-7-15-38(33)73-43)59(55(90)91,48(83)44(31-79)76-51(86)41(24-32-11-4-3-5-12-32)74-46(81)30-72-50(85)40-26-34(80)28-70-40)36(18-21-69-58(65)66)47(82)45-17-10-22-77(45)52(87)39(16-9-20-68-57(63)64)75-49(84)37(60)14-8-19-67-56(61)62/h3-5,11-12,33-45,70-71,73,79-80H,2,6-10,13-31,60H2,1H3,(H,72,85)(H,74,81)(H,75,84)(H,76,86)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,34?,35-,36?,37+,38-,39-,40-,41-,42+,43?,44-,45-,59-/m0/s1

SMILES Code

CCCO[C@H]1C[C@@H](NC1)C(=O)N(C(=O)C2C[C@@H]3CCCC[C@@H]3N2)[C@@](C(CCNC(=N)N)C(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)N)(C(=O)[C@H](CO)NC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)[C@@H]6CC(CN6)O)C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,294.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Houle S, Larrivée JF, Bachvarova M, Bouthillier J, Bachvarov DR, Marceau F. Antagonist-induced intracellular sequestration of rabbit bradykinin B(2) receptor. Hypertension. 2000 Jun;35(6):1319-25. PubMed PMID: 10856284. 2: Ikemura T, Sasaki Y, Ohmori K. Inhibitory effect of NPC-17731 on BK-induced and antigen-induced airway reactions in guinea-pigs. Clin Exp Allergy. 1998 May;28(5):635-43. PubMed PMID: 9645601. 3: Medeiros YS, Calixto JB. Competitive and selective antagonistic action of NPC 17731 on bradykinin-induced relaxant and contractile responses of the guinea pig isolated ileum. Gen Pharmacol. 1995 Nov;26(7):1507-11. PubMed PMID: 8690237.