HIF-1α inhibitor-1 | CAS# 1000025-14-8 | HIF-1alpha Inhibitor

MedKoo Cat#: 564699 | Name: HIF-1α inhibitor-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.

Chemical Structure

HIF-1α inhibitor-1

CAS#1000025-14-8

Theoretical Analysis

MedKoo Cat#: 564699

Name: HIF-1α inhibitor-1

CAS#: 1000025-14-8

Chemical Formula: C15H11N3O4

Exact Mass: 297.0750

Molecular Weight: 297.27

Elemental Analysis: C, 60.61; H, 3.73; N, 14.14; O, 21.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HIF1α inhibitor-1; HIF 1α inhibitor 1; HIF-1α inhibitor-1

IUPAC/Chemical Name

2-[[5-(4-Cyanophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid

InChi Key

FUWDGRQRRUDDDA-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)

SMILES Code

O=C(O)CNC(C1=NC=C(C2=CC=C(C#N)C=C2)C=C1O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 297.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Song QQ, Niu JP, Zhang SY, Liang TT, Zhou J, Feng SS. Effects of Simulated Heat Wave and Ozone on High Fat Diet ApoE Deficient Mice. Biomed Environ Sci. 2018 Oct;31(10):757-768. doi: 10.3967/bes2018.101. PubMed PMID: 30423277. 2: Zhang D, Liu Y, Tang Y, Wang X, Li Z, Li R, Ti Z, Gao W, Bai J, Lv Y. Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death. PLoS One. 2018 May 16;13(5):e0197266. doi: 10.1371/journal.pone.0197266. eCollection 2018. PubMed PMID: 29768513; PubMed Central PMCID: PMC5955518. 3: Pahima H, Reina S, Tadmor N, Dadon-Klein D, Shteinfer-Kuzmine A, Mazure NM, De Pinto V, Shoshan-Barmatz V. Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities. Oncotarget. 2018 Jan 31;9(16):12825-12841. doi: 10.18632/oncotarget.24377. eCollection 2018 Feb 27. PubMed PMID: 29560113; PubMed Central PMCID: PMC5849177.