MedKoo Cat#: 573255 | Name: AR-LH31

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-LH31 is a drug which has anti-arrhythmic activity. In one study, the administration of AR-LH31 by intravenous injection did not abolish ventricular arrhythmia but increased the number of sinus beats.

Chemical Structure

AR-LH31
CAS#69835-39-8

Theoretical Analysis

MedKoo Cat#: 573255

Name: AR-LH31

CAS#: 69835-39-8

Chemical Formula: C25H32Cl2N4O2

Exact Mass: 490.1902

Molecular Weight: 491.46

Elemental Analysis: C, 61.10; H, 6.56; Cl, 14.43; N, 11.40; O, 6.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AR-LH31
IUPAC/Chemical Name
1H-Imidazo(4,5-h)isoquinoline-7,9(6H,8H)-dione, 8-(3-(diethylamino)propyl)-6,6-dimethyl-2-phenyl-, dihydrochloride
InChi Key
MSZMZKUZIWGHEN-UHFFFAOYSA-N
InChi Code
1S/C25H30N4O2.2ClH/c1-5-28(6-2)15-10-16-29-23(30)20-18(25(3,4)24(29)31)13-14-19-21(20)27-22(26-19)17-11-8-7-9-12-17;;/h7-9,11-14H,5-6,10,15-16H2,1-4H3,(H,26,27);2*1H
SMILES Code
C1(c2c3c(ccc2C(C(=O)N1CCCN(CC)CC)(C)C)nc([nH]3)c1ccccc1)=O.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 491.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Honerjäger P, Loibl E, Steidl I, Schönsteiner G, Ulm K. Negative inotropic effects of tetrodotoxin and seven class 1 antiarrhythmic drugs in relation to sodium channel blockade. Naunyn Schmiedebergs Arch Pharmacol. 1986 Feb;332(2):184-95. PubMed PMID: 2422563. 2: Kerr MJ, Harron DW, Wilson R, Shanks RG. Effect of 8-(3-diethylaminopropyl)-6,6-dimethyl-(2-phenyl-1 H-imidazo(4,5 h))isoquinoline-7,9-(6H)-dione dihydrochloride (AR-LH31) on experimental cardiac arrhythmias in dogs. Arzneimittelforschung. 1985;35(1A):197-200. PubMed PMID: 3838674.