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MedKoo Cat#: 573254 | Name: AR-L 57 CL

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-L 57 CL is a cardiotonic agent.

Chemical Structure

AR-L 57 CL
CAS#61393-38-2

Theoretical Analysis

MedKoo Cat#: 573254

Name: AR-L 57 CL

CAS#: 61393-38-2

Chemical Formula: C14H13N3O2

Exact Mass: 255.1008

Molecular Weight: 255.28

Elemental Analysis: C, 65.87; H, 5.13; N, 16.46; O, 12.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AR-L 57 CL
IUPAC/Chemical Name
1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-
InChi Key
ZAFBRSZVPHJXGB-UHFFFAOYSA-N
InChi Code
1S/C14H13N3O2.ClH/c1-18-9-5-6-10(12(8-9)19-2)13-16-11-4-3-7-15-14(11)17-13;/h3-8H,1-2H3,(H,15,16,17);1H
SMILES Code
c12c(cccn1)[nH]c(n2)c1c(cc(cc1)OC)OC.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Heusch G, Schäfer S, Kröger K. Recruitment of inotropic reserve in "stunned" myocardium by the cardiotonic agent AR-L 57. Basic Res Cardiol. 1988 Nov-Dec;83(6):602-10. PubMed PMID: 3223876. 2: Hayes JS, Wyss VL, Wilson H, Pollock GD. A comparison of the cardiotonic effects of AR-L115 and AR-L57: evidence for distinct inotropic mechanisms. J Cardiovasc Pharmacol. 1985 Jan-Feb;7(1):182-9. PubMed PMID: 2580141. 3: Diederen W, Kadatz R. Comparative cardiovascular effects of three benzimidazole derivatives, AR-L 57 BS, AR-L 100 BS, and AR-L 115 BS. Arzneimittelforschung. 1981;31(1a):141-6. PubMed PMID: 7195207. 4: Honerjäger P, Reiter M, Baker PF. Effect of the cardioactive drug AR-L 57 on free intracellular calcium and ouabain-insensitive ion fluxes in the squid giant axon. Mol Pharmacol. 1981 Jan;19(1):68-77. PubMed PMID: 6163073. 5: Honerjäger P, Reiter M, Baker PF. Inhibition of the sodium pump in squid axons by the cardioactive drug AR-L 57. Mol Pharmacol. 1980 May;17(3):350-5. PubMed PMID: 7393213.