VZ185 is a PROTAC (Proteolysis-Targeting Chimera) molecule designed to degrade BRD4 (Bromodomain-containing protein 4), a key epigenetic regulator involved in transcriptional control and cancer progression. It functions by recruiting BRD4 to the E3 ubiquitin ligase system, leading to its ubiquitination and subsequent degradation via the proteasome pathway. This targeted protein degradation disrupts oncogenic transcription programs, making VZ185 a promising therapeutic candidate for cancer treatment, particularly in acute myeloid leukemia (AML) and other BRD4-dependent malignancies.
MedKoo Cat#: 207079
Name: VZ185
CAS#: 2306193-61-1
Chemical Formula: C53H67FN8O8S
Exact Mass: 994.4787
Molecular Weight: 995.23
Elemental Analysis: C, 63.96; H, 6.79; F, 1.91; N, 11.26; O, 12.86; S, 3.22
The following data is based on the product molecular weight 995.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
