Olafertinib, also known as CK-101 and Olafertinib, is a potent and orally active EGFR mutant-specific inhibitor. CK-101 specifically and covalently binds to and inhibits specific EGFR mutations, with particularly high selectivity against the T790M mutation; this prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CK-101 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
MedKoo Cat#: 207019
Name: Olafertinib
CAS#: 1660963-42-7
Chemical Formula: C29H28F2N6O2
Exact Mass: 530.2242
Molecular Weight: 530.58
Elemental Analysis: C, 65.65; H, 5.32; F, 7.16; N, 15.84; O, 6.03
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 125.0 | 235.59 |
The following data is based on the product molecular weight 530.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
