MedKoo Cat#: 573235 | Name: Harmaline
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Harmaline is a beta-carboline alkaloid isolated from seeds of PEGANUM. It is a psychoactive indole with stimulating activities achieved, in part, through inhibition of monoamine oxidases. Harmaline induces tremor in mice through the N-methyl-D-aspartate (NMDA) receptor, at which harmaline may act as an inverse agonist.

Chemical Structure

Harmaline
Harmaline
CAS#304-21-2

Theoretical Analysis

MedKoo Cat#: 573235

Name: Harmaline

CAS#: 304-21-2

Chemical Formula: C13H14N2O

Exact Mass: 214.1106

Molecular Weight: 214.27

Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

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1g USD 450.00 2 Weeks
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Related CAS #
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Synonym
Harmaline; Dihydroharmine; Harmidine; Armalin; 3,4-Dihydroharmine; Harmalol methyl ether; O-Methylharmalol; NSC 407285; NSC407285 NSC-407285
IUPAC/Chemical Name
3H-Pyrido(3,4-b)indole, 4,9-dihydro-7-methoxy-1-methyl-
InChi Key
RERZNCLIYCABFS-UHFFFAOYSA-N
InChi Code
1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3
SMILES Code
c12c3c([nH]c1C(=NCC2)C)cc(cc3)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Siddiqui H, Tasneem S, Farooq S, Sami A, Rahman AU, Choudhary MI. Harmaline and its Derivatives Against the Infectious Multi-Drug Resistant Escherichia coli. Med Chem. 2017;13(5):465-476. doi: 10.2174/1573406413666170125113832. PubMed PMID: 28124613. 2: Abdulrahman AA, Faisal K, Meshref AA, Arshaduddin M. Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats. Neurol Res. 2017 Mar;39(3):264-270. doi: 10.1080/01616412.2016.1275456. Epub 2017 Jan 18. PubMed PMID: 28095756. 3: Jiang XL, Shen HW, Yu AM. Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms. Pharmacol Rep. 2016 Jun;68(3):608-15. doi: 10.1016/j.pharep.2016.01.008. Epub 2016 Feb 5. PubMed PMID: 26977821; PubMed Central PMCID: PMC4848137.