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MedKoo Cat#: 573234 | Name: Fpl 12495

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fpl 12495, also known as ARL-12495AA, is the (S,R)-isomer monohydrochloride metabolite of Remacemide. Fpl 12495 acts as an anti-convulsant.

Chemical Structure

Fpl 12495
Fpl 12495
CAS#118910-28-4

Theoretical Analysis

MedKoo Cat#: 573234

Name: Fpl 12495

CAS#: 118910-28-4

Chemical Formula: C15H18ClN

Exact Mass: 247.1128

Molecular Weight: 247.77

Elemental Analysis: C, 72.72; H, 7.32; Cl, 14.31; N, 5.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ARL-12495AA, Fpl 12495, Fpl 12495AA
IUPAC/Chemical Name
1-Methyl-1,2-diphenylethylamine monohydrochloride
InChi Key
JINQHBRSXWQJAZ-UHFFFAOYSA-N
InChi Code
1S/C15H17N/c1-15(16,14-10-6-3-7-11-14)12-13-8-4-2-5-9-13/h2-11H,12,16H2,1H3
SMILES Code
c1(ccccc1)C[C@@](N)(c1ccccc1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Asghar AU, Hasan SS, King AE. Actions of the anticonvulsant remacemide metabolite AR-R12495AA on afferent-evoked spinal synaptic transmission in vitro and on models of acute and chronic inflammation in the rat. J Pharmacol Exp Ther. 2000 Sep;294(3):876-83. PubMed PMID: 10945836. 2: Norris SK, King AE. The stereo-isomers of the anticonvulsant ARL 12495AA limit sustained repetitive firing and modify action potential properties of rat hippocampal neurons in vitro. J Pharmacol Exp Ther. 1997 Jun;281(3):1191-8. PubMed PMID: 9190853. 3: Wamil AW, Cheung H, Harris EW, McLean MJ. Remacemide HCl and its metabolite, FPL 12495AA, limit action potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture. Epilepsy Res. 1996 Feb;23(1):1-14. PubMed PMID: 8925800. 4: Srinivasan J, Richens A, Davies JA. The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex. Br J Pharmacol. 1995 Dec;116(8):3087-92. PubMed PMID: 8719781; PubMed Central PMCID: PMC1909187. 5: van Luijtelaar EL, Coenen AM. Effects of remacemide and its metabolite FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy. Neuropharmacology. 1995 Apr;34(4):419-25. PubMed PMID: 7566473.