Synonym
Ethyl 702; Etil 702; Ionox 220; Ionox 220 antioxidant; L 3MB1; LZ-MB 1; MB 1 (Antioxidant); MB 1 (antioxidant) (VAN); NSC 30551;
IUPAC/Chemical Name
2,2',6,6'-Tetra-tert-butyl-4,4'-methylenediphenol
InChi Key
MDWVSAYEQPLWMX-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H44O2/c1-26(2,3)20-14-18(15-21(24(20)30)27(4,5)6)13-19-16-22(28(7,8)9)25(31)23(17-19)29(10,11)12/h14-17,30-31H,13H2,1-12H3
SMILES Code
OC1=C(C(C)(C)C)C=C(CC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C=C1C(C)(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Ionox-220 is an Antioxidant.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
424.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Princz J, Bonnell M, Ritchie E, Velicogna J, Robidoux PY, Scroggins R. Estimation of the bioaccumulation potential of a nonchlorinated bisphenol and an ionogenic xanthene dye to Eisenia andrei in field-collected soils, in conjunction with predictive in silico profiling. Environ Toxicol Chem. 2014 Feb;33(2):308-16. PubMed PMID: 24173968.
2: Ritchie EE, Princz JI, Robidoux PY, Scroggins RP. Ecotoxicity of xanthene dyes and a non-chlorinated bisphenol in soil. Chemosphere. 2013 Feb;90(7):2129-35. doi: 10.1016/j.chemosphere.2012.10.096. Epub 2012 Dec 1. PubMed PMID: 23211322.
3: Quinchia LA, Delgado MA, Valencia C, Franco JM, Gallegos C. Natural and synthetic antioxidant additives for improving the performance of new biolubricant formulations. J Agric Food Chem. 2011 Dec 28;59(24):12917-24. doi: 10.1021/jf2035737. Epub 2011 Dec 1. PubMed PMID: 22103562.
4: Amorati R, Lucarini M, Mugnaini V, Pedulli GF. Antioxidant activity of o-bisphenols: the role of intramolecular hydrogen bonding. J Org Chem. 2003 Jun 27;68(13):5198-204. PubMed PMID: 12816477.
5: Takahashi O, Hiraga K. Effects of four bisphenolic antioxidants on lipid contents of rat liver. Toxicol Lett. 1981 Apr;8(1-2):77-86. PubMed PMID: 7245245.
6: Takahashi O, Hiraga K. Effects of four bisphenolic antioxidants on prothrombin levels of rat plasma. Toxicol Lett. 1981 Mar;7(6):405-8. PubMed PMID: 7245226.
