Ranakinin | CAS#139446-71-2

MedKoo Cat#: 530721 | Name: Ranakinin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ranakinin is a novel tachykinin receptor agonist; from the brain of frog, Rana ridibunda.

Chemical Structure

Ranakinin

CAS#139446-71-2

Theoretical Analysis

MedKoo Cat#: 530721

Name: Ranakinin

CAS#: 139446-71-2

Chemical Formula: C62H95N17O15S

Exact Mass: 1349.6914

Molecular Weight: 1350.61

Elemental Analysis: C, 55.14; H, 7.09; N, 17.63; O, 17.77; S, 2.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ranakinin

IUPAC/Chemical Name

Lys-pro-asn-pro-glu-arg-phe-tyr-gly-leu-met-NH2

InChi Key

YTZYDDAKFLJJQR-BHEJXMHWSA-N

InChi Code

InChI=1S/C62H95N17O15S/c1-35(2)30-43(56(89)72-40(52(66)85)24-29-95-3)71-50(82)34-70-53(86)44(32-37-18-20-38(80)21-19-37)75-57(90)45(31-36-12-5-4-6-13-36)76-54(87)41(15-9-26-69-62(67)68)73-55(88)42(22-23-51(83)84)74-58(91)48-17-11-28-79(48)61(94)46(33-49(65)81)77-59(92)47-16-10-27-78(47)60(93)39(64)14-7-8-25-63/h4-6,12-13,18-21,35,39-48,80H,7-11,14-17,22-34,63-64H2,1-3H3,(H2,65,81)(H2,66,85)(H,70,86)(H,71,82)(H,72,89)(H,73,88)(H,74,91)(H,75,90)(H,76,87)(H,77,92)(H,83,84)(H4,67,68,69)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1

SMILES Code

O=C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,350.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang B, Zhang X, Yang Y, Hu Y, Wang H. Identification and Functional Analysis of Novel Bradykinin-Related Peptides (BRPs) from Skin Secretions of Five Asian Frogs. Protein J. 2018 Aug;37(4):324-332. doi: 10.1007/s10930-018-9783-9. PubMed PMID: 30008150. 2: Liu X, You D, Chen L, Wang X, Zhang K, Lai R. A novel bradykinin-like peptide from skin secretions of the frog, Rana nigrovittata. J Pept Sci. 2008 May;14(5):626-30. PubMed PMID: 17994619. 3: Liu L, Murray M, Conlon JM, Burcher E. Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2005 Jan 15;69(2):329-38. Epub 2004 Dec 1. PubMed PMID: 15627485. 4: Liu L, Murray M, Burcher E. Structure-activity studies of bufokinin, substance P and their C-terminal fragments at bufokinin receptors in the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2002 Jan 15;63(2):217-24. PubMed PMID: 11841796. 5: Lippe C, Lobasso S, Cassano G, Bellantuono V, Ardizzone C. Actions of tachykinins on the ion transport across the frog skin. Peptides. 1998;19(8):1435-8. PubMed PMID: 9809659. 6: Burcher E, Warner FJ. Tachykinin receptors in the small intestine of the cane toad (Bufo marinus): a radioligand binding and functional study. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jun;357(6):692-700. PubMed PMID: 9686947. 7: Kodjo MK, Desrues L, Lavagno L, Fasolo A, Conlon JM, Tonon MC, Vaudry H. Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. Endocrinology. 1998 Feb;139(2):505-12. PubMed PMID: 9449618. 8: Kodjo MK, Leboulenger F, Morra M, Conlon JM, Vaudry H. Pharmacological profile of the tachykinin receptor involved in the stimulation of corticosteroid secretion in the frog Rana ridibunda. J Steroid Biochem Mol Biol. 1996 Mar;57(5-6):329-35. PubMed PMID: 8639469. 9: Kodjo MK, Leboulenger F, Conlon JM, Vaudry H. Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells. Endocrinology. 1995 Oct;136(10):4535-42. PubMed PMID: 7664674. 10: Kodjo MK, Leboulenger F, Porcedda P, Lamacz M, Conlon JM, Pelletier G, Vaudry H. Evidence for the involvement of chromaffin cells in the stimulatory effect of tachykinins on corticosteroid secretion by the frog adrenal gland. Endocrinology. 1995 Aug;136(8):3253-9. PubMed PMID: 7628358. 11: Leboulenger F, Vaglini L, Conlon JM, Homo-Delarche F, Wang Y, Kerdelhue B, Pelletier G, Vaudry H. Immunohistochemical distribution, biochemical characterization, and biological action of tachykinins in the frog adrenal gland. Endocrinology. 1993 Nov;133(5):1999-2008. PubMed PMID: 7691584. 12: Badgery-Parker T, Lovas S, Conlon JM, Burcher E. Receptor binding profile of neuropeptide gamma and its fragments: comparison with the nonmammalian peptides carassin and ranakinin at three mammalian tachykinin receptors. Peptides. 1993 Jul-Aug;14(4):771-5. PubMed PMID: 8234024. 13: Courtice GP, Burcher E, Carlo-Stella R, Conlon JM. Cardiovascular effects of amphibian and mammalian tachykinins in the toad, Bufo marinus. Neuropeptides. 1993 Mar;24(3):171-6. PubMed PMID: 7682677. 14: O'Harte F, Burcher E, Lovas S, Smith DD, Vaudry H, Conlon JM. Ranakinin: a novel NK1 tachykinin receptor agonist isolated with neurokinin B from the brain of the frog Rana ridibunda. J Neurochem. 1991 Dec;57(6):2086-91. PubMed PMID: 1658233. 15: Yasuhara T, Ishikawa O, Nakajima T, Araki K, Tachibana S. The studies on the active peptide on smooth muscle in the skin of Rana rugosa, Thr6-Bradykinin and its analogous peptide, ranakinin-R. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):486-91. PubMed PMID: 445684.