MedKoo Cat#: 530716 | Name: Interleukin 1beta

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Interleukin 1beta is a bioactive chemical.

Chemical Structure

Interleukin 1beta
Interleukin 1beta
CAS#117027-34-6

Theoretical Analysis

MedKoo Cat#: 530716

Name: Interleukin 1beta

CAS#: 117027-34-6

Chemical Formula: C15H28N4O5

Exact Mass: 344.2060

Molecular Weight: 344.41

Elemental Analysis: C, 52.31; H, 8.19; N, 16.27; O, 23.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Interleukin 1beta
IUPAC/Chemical Name
L-Threonine, N-(1-L-lysyl-D-prolyl)-
InChi Key
LOGFVTREOLYCPF-KXNHARMFSA-N
InChi Code
InChI=1S/C15H28N4O5/c1-9(20)12(15(23)24)18-13(21)11-6-4-8-19(11)14(22)10(17)5-2-3-7-16/h9-12,20H,2-8,16-17H2,1H3,(H,18,21)(H,23,24)/t9-,10+,11-,12+/m1/s1
SMILES Code
C[C@@H](O)[C@@H](C(O)=O)NC([C@@H]1N(C([C@H](CCCCN)N)=O)CCC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nan K, Han Y, Fang Q, Huang C, Yu L, Ge W, Xiang F, Tao YX, Cao H, Li J. HMGB1 gene silencing inhibits neuroinflammation via down-regulation of NF-κB signaling in primary hippocampal neurons induced by Aβ(25-35). Int Immunopharmacol. 2018 Dec 17;67:294-301. doi: 10.1016/j.intimp.2018.12.027. [Epub ahead of print] PubMed PMID: 30572254. 2: Hu X, Shen H, Wang Y, Zhang L, Zhao M. Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. Life Sci. 2018 Dec 17. pii: S0024-3205(18)30821-X. doi: 10.1016/j.lfs.2018.12.028. [Epub ahead of print] PubMed PMID: 30571954. 3: Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca(2+)/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 Nov 27;138(22):2530-2544. doi: 10.1161/CIRCULATIONAHA.118.034621. PubMed PMID: 30571348. 4: Kim ML, Martin WJ, Minigo G, Keeble JL, Garnham AL, Pacini G, Smyth GK, Speed TP, Carapetis J, Wicks IP. Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine. Circulation. 2018 Dec 4;138(23):2648-2661. doi: 10.1161/CIRCULATIONAHA.118.033891. PubMed PMID: 30571257. 5: Wang W, Zhong X, Li Y, Guo R, Du S, Wen L, Ying Y, Yang T, Wei XH. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic postoperative pain. J Neurochem. 2018 Dec 20. doi: 10.1111/jnc.14650. [Epub ahead of print] PubMed PMID: 30570747. 6: Liu H, Dong H, Zhou N, Dong S, Chen L, Zhu Y, Hu HM, Mou Y. SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β. Nanoscale Res Lett. 2018 Dec 20;13(1):409. doi: 10.1186/s11671-018-2802-0. PubMed PMID: 30570682. 7: Li Q, Ye T, Long T, Peng X. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2018 Dec 20:1-9. doi: 10.1080/09168451.2018.1553608. [Epub ahead of print] PubMed PMID: 30570395. 8: Lee Y, Pham TX, Bae M, Hu S, O'Neill E, Chun OK, Han MJ, Koo SI, Park YK, Lee JY. Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice. Obesity (Silver Spring). 2019 Jan;27(1):112-120. doi: 10.1002/oby.22353. PubMed PMID: 30569636. 9: Ren S, Chen X, Huang R, Zhou GG, Yuan Z. SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model. Oncol Rep. 2018 Dec 18. doi: 10.3892/or.2018.6935. [Epub ahead of print] PubMed PMID: 30569160. 10: Wang S, Ji LY, Li L, Li JM. Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen induced retinopathy in mice. Mol Med Rep. 2018 Dec 13. doi: 10.3892/mmr.2018.9759. [Epub ahead of print] PubMed PMID: 30569132. 11: Ding Y, Wang L, Zhao Q, Wu Z, Kong L. MicroRNA 93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF κB signaling pathway. Int J Mol Med. 2018 Dec 18. doi: 10.3892/ijmm.2018.4033. [Epub ahead of print] PubMed PMID: 30569118. 12: Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, Lv Y, Liu Q, Guo C, Zhou Y. Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways. Drug Des Devel Ther. 2018 Nov 29;12:4067-4082. doi: 10.2147/DDDT.S182292. eCollection 2018. PubMed PMID: 30568428; PubMed Central PMCID: PMC6276616. 13: Liu RH, Wen Y, Sun HY, Liu CY, Zhang YF, Yang Y, Huang QL, Tang JJ, Huang CC, Tang LJ. Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages. World J Gastroenterol. 2018 Dec 7;24(45):5131-5143. doi: 10.3748/wjg.v24.i45.5131. PubMed PMID: 30568390; PubMed Central PMCID: PMC6288649. 14: Lu Y, Wang X, Yang G, Liu X, Xu M. Effects of Chronic Intractable Insomnia on Inflammatory Cytokines, Blood Pressure Characteristics, and Antihypertensive Efficacy in Hypertensive Patients. Med Sci Monit. 2018 Dec 20;24:9259-9264. doi: 10.12659/MSM.911997. PubMed PMID: 30568156. 15: Ramos-Benitez MJ, Ruiz-Jimenez C, Rosado-Franco JJ, Ramos-Pérez WD, Mendez LB, Osuna A, Espino AM. Fh15 Blocks the Lipopolysaccharide-Induced Cytokine Storm While Modulating Peritoneal Macrophage Migration and CD38 Expression within Spleen Macrophages in a Mouse Model of Septic Shock. mSphere. 2018 Dec 19;3(6). pii: e00548-18. doi: 10.1128/mSphere.00548-18. PubMed PMID: 30567900. 16: Wang JS, Xiao WW, Zhong YS, Li XD, Du SX, Xie P, Zheng GZ, Han JM. Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway. J Cell Biochem. 2018 Dec 19. doi: 10.1002/jcb.28304. [Epub ahead of print] PubMed PMID: 30565728. 17: Stone SJ, Kumar PS, Offenbacher S, Heasman PA, McCracken GI. Exploring a temporal relationship between biofilm microbiota and inflammatory mediators during resolution of naturally-occurring gingivitis. J Periodontol. 2018 Dec 19. doi: 10.1002/JPER.18-0156. [Epub ahead of print] PubMed PMID: 30565232. 18: Wei Y, Troger A, Spahiu V, Perekhvatova N, Skulachev M, Petrov A, Chernyak B, Asbell P. The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface. Ophthalmol Ther. 2018 Dec 18. doi: 10.1007/s40123-018-0158-2. [Epub ahead of print] PubMed PMID: 30565203. 19: Sur B, Kang S, Kim M, Oh S. Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative. Inflammation. 2018 Dec 19. doi: 10.1007/s10753-018-0947-8. [Epub ahead of print] PubMed PMID: 30565030. 20: Gómez GI, Falcon RV, Maturana CJ, Labra VC, Salgado N, Rojas CA, Oyarzun JE, Cerpa W, Quintanilla RA, Orellana JA. Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. Front Cell Neurosci. 2018 Dec 4;12:472. doi: 10.3389/fncel.2018.00472. eCollection 2018. PubMed PMID: 30564103; PubMed Central PMCID: PMC6288256.