MedKoo Cat#: 573213 | Name: APO-6619

Description:

WARNING: This product is for research use only, not for human or veterinary use.

APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. APO-6619 may be useful as a non-traditional treatment of bacterial infections.

Chemical Structure

APO-6619
APO-6619
CAS#887774-94-9

Theoretical Analysis

MedKoo Cat#: 573213

Name: APO-6619

CAS#: 887774-94-9

Chemical Formula: C11H14N2O3

Exact Mass: 222.1004

Molecular Weight: 222.24

Elemental Analysis: C, 59.45; H, 6.35; N, 12.61; O, 21.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
APO-6619
IUPAC/Chemical Name
1-Cyclopropyl-3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid methylamide
InChi Key
GYWMPYYHESRUBP-UHFFFAOYSA-N
InChi Code
1S/C11H14N2O3/c1-6-5-8(14)10(15)9(11(16)12-2)13(6)7-3-4-7/h5,7,15H,3-4H2,1-2H3,(H,12,16)
SMILES Code
CNC(=O)C1=C(O)C(=O)C=C(C)N1C2CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 222.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Thompson MG, Corey BW, Si Y, Craft DW, Zurawski DV. Antibacterial activities of iron chelators against common nosocomial pathogens. Antimicrob Agents Chemother. 2012 Oct;56(10):5419-21. doi: 10.1128/AAC.01197-12. Epub 2012 Jul 30. PubMed PMID: 22850524; PubMed Central PMCID: PMC3457357.