Bursopoietin | CAS#60267-34-7

MedKoo Cat#: 530702 | Name: Bursopoietin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bursopoietin Cell differentiation agent in extracts of chicken bursa of fabricus.

Chemical Structure

Bursopoietin

CAS#60267-34-7

Theoretical Analysis

MedKoo Cat#: 530702

Name: Bursopoietin

CAS#: 60267-34-7

Chemical Formula: C14H25N7O3

Exact Mass: 339.2019

Molecular Weight: 339.40

Elemental Analysis: C, 49.54; H, 7.42; N, 28.89; O, 14.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Bursopoietin

IUPAC/Chemical Name

Lysyl-histidyl-glycinamide

InChi Key

DIBAKBGYJUCGDL-QWRGUYRKSA-N

InChi Code

InChI=1S/C14H25N7O3/c15-4-2-1-3-10(16)13(23)21-11(5-9-6-18-8-20-9)14(24)19-7-12(17)22/h6,8,10-11H,1-5,7,15-16H2,(H2,17,22)(H,18,20)(H,19,24)(H,21,23)/t10-,11-/m0/s1

SMILES Code

O=C(N)CNC([C@H](CC1=CNC=N1)NC([C@H](CCCCN)N)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 339.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang C, Li X, Wu T, Li D, Niu M, Wang Y, Zhang C, Cheng X, Chen P. Bursin-like peptide (BLP) enhances H9N2 influenza vaccine induced humoral and cell mediated immune responses. Cell Immunol. 2014 Nov-Dec;292(1-2):57-64. doi: 10.1016/j.cellimm.2014.09.003. Epub 2014 Oct 4. PubMed PMID: 25282449. 2: Shen X, Yi D, Ni X, Zeng D, Jing B, Lei M, Bian Z, Zeng Y, Li T, Xin J. Effects of Lactobacillus plantarum on production performance, immune characteristics, antioxidant status, and intestinal microflora of bursin-immunized broilers. Can J Microbiol. 2014 Apr;60(4):193-202. doi: 10.1139/cjm-2013-0680. Epub 2014 Feb 13. PubMed PMID: 24693977. 3: Wang C, Zhao Z, Niu M, Zhang C, Cheng X, Chen P. [Expression of bursin receptor on membranes of hybridoma cell and identification of binding peptide of bursin from 12-merrandom phage display peptide library]. Wei Sheng Wu Xue Bao. 2010 Feb;50(2):270-7. Chinese. PubMed PMID: 20387472. 4: Wang C, Wen WY, Su CX, Ge FF, Dang ZG, Duan XG, Cao RB, Zhou B, Chen PY. Bursin as an adjuvant is a potent enhancer of immune response in mice immunized with the JEV subunit vaccine. Vet Immunol Immunopathol. 2008 Apr 15;122(3-4):265-74. doi: 10.1016/j.vetimm.2007.11.010. Epub 2007 Dec 4. PubMed PMID: 18191231. 5: Guo S, Chen NH, Guan R, Feng J, Huang W. Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck). Poult Sci. 2006 Feb;85(2):258-65. PubMed PMID: 16523625. 6: Tutel'yan AV, Klebanov GI, Il'ina SE, Lyubitskii OB. Comparative study of antioxidant properties of immunoregulatory peptides. Bull Exp Biol Med. 2003 Aug;136(2):155-8. PubMed PMID: 14631497. 7: Chen NH, Wu SJ. [Analysis on the characteristics of histological location of bursin in immune organ of chicken and duck]. Shi Yan Sheng Wu Xue Bao. 2003 Apr;36(2):155-62. Chinese. PubMed PMID: 12858515. 8: Otsubo Y, Chen N, Kajiwara E, Horiuchi H, Matsuda H, Furusawa S. Role of bursin in the development of B lymphocytes in chicken embryonic Bursa of Fabricius. Dev Comp Immunol. 2001 Jun-Jul;25(5-6):485-93. PubMed PMID: 11356228. 9: Gagnon L, DiMarco M, Kirby R, Zacharie B, Penney CL. D-LysAsnProTyr tetrapeptide: a novel B-cell stimulant and stabilized bursin mimetic. Vaccine. 2000 Mar 17;18(18):1886-92. PubMed PMID: 10699337. 10: Youbicier-Simo BJ, Boudard F, Mékaouche M, Baylé JD, Bastide M. A role for bursa fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken. J Pineal Res. 1996 Aug;21(1):35-43. PubMed PMID: 8836962. 11: Zhang HW, Xu YT, Wang HR. [The material isolated from bovine liver promoted the immunity of chicken]. Shi Yan Sheng Wu Xue Bao. 1995 Jun;28(2):111-9. Chinese. PubMed PMID: 7571945. 12: Abiko T, Sekino H. Syntheses and effect of bursin and it analogs on the reduced B lymphocytes of uremic patients. Biotechnol Ther. 1994-1995;5(3-4):163-70. PubMed PMID: 8608325. 13: Guellati M, Ramade F, Le Nguyen D, Ibos F, Bayle JD. Effects of early embryonic bursectomy and opotherapic substitution on the functional development of the adrenocorticotropic axis. J Dev Physiol. 1991 Jun;15(6):357-63. PubMed PMID: 1661311. 14: Audhya T, King R, Goldstein G. Bovine probursin tetradecapeptide contains amino acid sequence from somatostatin, tuftsin and bursin. Life Sci. 1991;48(8):773-80. PubMed PMID: 1671611. 15: Audhya T, Viamontes G, Babu U, Goldstein G. Bursin localization in mammalian bone marrow and epithelial cells of intrahepatic bile ducts. Scand J Immunol. 1990 Feb;31(2):199-204. PubMed PMID: 2408136. 16: Lassila O, Lambris JD, Gisler RH. A role for Lys-His-Gly-NH2 in avian and murine B cell development. Cell Immunol. 1989 Sep;122(2):319-28. PubMed PMID: 2788513. 17: Audhya T, Kroon D, Heavner G, Viamontes G, Goldstein G. Tripeptide structure of bursin, a selective B-cell-differentiating hormone of the bursa of fabricius. Science. 1986 Feb 28;231(4741):997-9. PubMed PMID: 3484838. 18: Brand A, Galton J, Gilmour DG. Committed precursors of B and T lymphocytes in chick embryo bursa of Fabricius, thymus, and bone marrow. Eur J Immunol. 1983 Jun;13(6):449-55. PubMed PMID: 6190659. 19: Goldstein G. Lymphocyte differentiations induced by thymopoietin, bursopoietin and ubiquitin. Symp Soc Dev Biol. 1978;(35):197-202. PubMed PMID: 205966. 20: Goldstein G, Scheid M, Boyse EA, Brand A, Gilmour DG. Thymopoietin and bursopoietin: induction signals regulating early lymphocyte differentiation. Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:5-8. PubMed PMID: 196805.