MAP3K14-IN-173 | CAS# 2113617-02-8 | MAP3K14 Kinase Inhibitor

MedKoo Cat#: 564668 | Name: MAP3K14-IN-173

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MAP3K14-IN-173 is a potent MAP3K14 kinase inhibitor.

Chemical Structure

MAP3K14-IN-173

CAS#2113617-02-8

Theoretical Analysis

MedKoo Cat#: 564668

Name: MAP3K14-IN-173

CAS#: 2113617-02-8

Chemical Formula: C29H31N7O2

Exact Mass: 509.2539

Molecular Weight: 509.61

Elemental Analysis: C, 68.35; H, 6.13; N, 19.24; O, 6.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MAP3K14-IN 173; MAP3K14 IN-173; MAP3K14 IN 173; MAP3K14-IN-173

IUPAC/Chemical Name

(R)-5-(2-((5-Cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile

InChi Key

VQBPWNWQPUQVHN-GDLZYMKVSA-N

InChi Code

InChI=1S/C29H31N7O2/c1-19-11-20(4-6-36-7-9-38-10-8-36)22(15-30)14-26(19)35-28-32-5-3-25(34-28)21-12-23(16-31)27-24(13-21)29(2,18-37)17-33-27/h3,5,11-14,33,37H,4,6-10,17-18H2,1-2H3,(H,32,34,35)/t29-/m1/s1

SMILES Code

N#CC1=CC(C2=NC(NC3=CC(C#N)=C(CCN4CCOCC4)C=C3C)=NC=C2)=CC5=C1NC[C@@]5(CO)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L. Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife. 2018 Aug 2;7. pii: e34152. doi: 10.7554/eLife.34152. PubMed PMID: 30070632; PubMed Central PMCID: PMC6078493. 2: Morgan GJ, He J, Tytarenko R, Patel P, Stephens OW, Zhong S, Deshpande S, Bauer M, Weinhold N, Schinke C, Rasche L, Bailey M, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Zangari M, van Rhee F, Mughal T, Davies FE, Walker BA. Kinase domain activation through gene rearrangement in multiple myeloma. Leukemia. 2018 Nov;32(11):2435-2444. doi: 10.1038/s41375-018-0108-y. Epub 2018 Mar 23. PubMed PMID: 29654269; PubMed Central PMCID: PMC6224403.