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MedKoo Cat#: 584732 | Name: Midesteine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Midesteine is a cyclic thiolic neutrophil elastase inhibitor.

Chemical Structure

Midesteine
Midesteine
CAS#94149-41-4

Theoretical Analysis

MedKoo Cat#: 584732

Name: Midesteine

CAS#: 94149-41-4

Chemical Formula: C12H13NO3S3

Exact Mass: 315.0058

Molecular Weight: 315.42

Elemental Analysis: C, 45.70; H, 4.15; N, 4.44; O, 15.22; S, 30.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Midesteine; MR 889; MR889; MR-889.
IUPAC/Chemical Name
2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester
InChi Key
RZSPDIRWSJHFTB-MQWKRIRWSA-N
InChi Code
InChI=1S/C12H13NO3S3/c1-7(16-12(17)9-3-2-5-18-9)10(14)13-8-4-6-19-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)/t7?,8-/m0/s1
SMILES Code
S=C(C1=CC=CS1)OC(C)C(N[C@@H](CCS2)C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Luisetti M, Piccioni PD, Donnini M, Peona V, Pozzi E, Grassi C. Studies of MR 889, a new synthetic proteinase inhibitor. Biochem Biophys Res Commun. 1989 Dec 15;165(2):568-73. PubMed PMID: 2597145. 2: Luisetti M, Piccioni PD, Donnini M, Alesina R, Donnetta AM, Peona V. On the activity of MR 889, a new synthetic proteinase inhibitor. Ann N Y Acad Sci. 1991;624:343-4. PubMed PMID: 1712157. 3: Gentili P, Pelloso R, La Rosa C, Galzigna L, Lucarelli C. Absorption, distribution, metabolism and excretion of 2-[2-thiophenecarboxythio]-N-[dihydro-2-(3H)-thiophenone-3-yl]-propiona mide in the rat. Arzneimittelforschung. 1990 Nov;40(11):1214-7. PubMed PMID: 2085332. 4: Luisetti M, Sturani C, Sella D, Madonini E, Galavotti V, Bruno G, Peona V, Kucich U, Dagnino G, Rosenbloom J, Starcher B, Grassi C. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial. Eur Respir J. 1996 Jul;9(7):1482-6. PubMed PMID: 8836663. 5: Ohbayashi H. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. Review. PubMed PMID: 12084007. 6: Baici A, Pelloso R, Hörler D. The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound. Biochem Pharmacol. 1990 Mar 1;39(5):919-24. PubMed PMID: 2310417. 7: Moretti M, Gorrini M, Donnetta AM, Baldini EV, Venturini R, Marchioni CF, Iadarola P, Luisetti M. Effects of MR889, a cyclic thiolic neutrophil elastase inhibitor, on rheologic properties of mucus. Life Sci. 1994;54(7):463-9. PubMed PMID: 8309349.

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