Lu AA27122 | α1A-Adrenoceptor Ligand

MedKoo Cat#: 564665 | Name: Lu AA27122

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lu AA27122 is a brain penetrant ligand with high affinity for α1A-adrenoceptor.

Chemical Structure

Lu AA27122

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564665

Name: Lu AA27122

CAS#: NONE

Chemical Formula: C24H23FN4

Exact Mass: 386.1907

Molecular Weight: 386.47

Elemental Analysis: C, 74.59; H, 6.00; F, 4.92; N, 14.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lu-AA27122; Lu AA27122; Lu AA-27122

IUPAC/Chemical Name

1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

InChi Key

WAWSGWZTHJAPIA-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H23FN4/c1-28-10-8-17(9-11-28)23-15-29(21-5-3-20(25)4-6-21)24-7-2-18(12-22(23)24)19-13-26-16-27-14-19/h2-7,12-17H,8-11H2,1H3

SMILES Code

CN1CCC(C2=CN(C3=CC=C(F)C=C3)C4=C2C=C(C5=CN=CN=C5)C=C4)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Airaksinen AJ, Finnema SJ, Balle T, Varnäs K, Bang-Andersen B, Gulyás B, Farde L, Halldin C. Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging. Nucl Med Biol. 2013 Aug;40(6):747-54. doi: 10.1016/j.nucmedbio.2013.05.007. Epub 2013 Jun 27. PubMed PMID: 23810488. 2: Jørgensen M, Jørgensen PN, Christoffersen CT, Jensen KG, Balle T, Bang-Andersen B. Discovery of novel α₁-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands. Bioorg Med Chem. 2013 Jan 1;21(1):196-204. doi: 10.1016/j.bmc.2012.10.049. Epub 2012 Nov 15. PubMed PMID: 23218776.