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MedKoo Cat#: 564662 | Name: Fluvastatin Methyl Ester
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluvastatin Methyl Ester is a precursor for Fluvastatin, which is a blocker of the liver enzyme HMG-CoA reductase.

Chemical Structure

Fluvastatin Methyl Ester
Fluvastatin Methyl Ester
CAS#93957-53-0

Theoretical Analysis

MedKoo Cat#: 564662

Name: Fluvastatin Methyl Ester

CAS#: 93957-53-0

Chemical Formula: C25H28FNO4

Exact Mass: 425.2002

Molecular Weight: 425.50

Elemental Analysis: C, 70.57; H, 6.63; F, 4.46; N, 3.29; O, 15.04

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 Back order
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Related CAS #
No Data
Synonym
Fluvastatin Methyl Ester
IUPAC/Chemical Name
Methyl (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
InChi Key
BOCZYIUKFAQNLG-DSJWGCTQSA-N
InChi Code
InChI=1S/C25H28FNO4/c1-16(2)27-22-7-5-4-6-21(22)25(17-8-10-18(26)11-9-17)23(27)13-12-19(28)14-20(29)15-24(30)31-3/h4-13,16,19-20,28-29H,14-15H2,1-3H3/b13-12+/t19-,20-/m0/s1
SMILES Code
O=C(OC)C[C@@H](O)C[C@@H](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Fluvastatin (XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
In vitro activity:
Fluvastatin significantly restored H2O2-induced neuronal death in a dose-dependent manner (P < 0.05) and reversed H2O2-induced oxidative stress and damage via restoring mitochondrial function in neuronal cells (P < 0.05). Reference: J Pharm Pharmacol. 2021 Mar 8;73(4):515-521. https://pubmed.ncbi.nlm.nih.gov/33793833/
In vivo activity:
Fluvastatin preconditioning in rats improved left ventricular dysfunction, reduced HMGB1/TLR4/NF-κB expressions, and inhibited cardiomyocyte apoptosis, autophagy, and inflammation reaction. Moreover, treatment with fluvastatin ameliorated myocardial injury by reducing infarct size, causing less damage to cardiac structure, downregulating autophagy-related protein expression and releasing pro-inflammation mediators. Reference: Mol Biol Rep. 2021 May;48(5):3893-3901. https://pubmed.ncbi.nlm.nih.gov/34032975/

Preparing Stock Solutions

The following data is based on the product molecular weight 425.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang M, Wang J, Liu M, Chen G. Fluvastatin protects neuronal cells from hydrogen peroxide-induced toxicity with decreasing oxidative damage and increasing PI3K/Akt/mTOR signalling. J Pharm Pharmacol. 2021 Mar 8;73(4):515-521. doi: 10.1093/jpp/rgaa058. PMID: 33793833. 2. Zhao K, Tian Y, Wang J, Chen C, Pan B, Yan Z, Zhu S, Xu K. Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2. Biomed Res Int. 2020 Dec 19;2020:7619849. doi: 10.1155/2020/7619849. PMID: 33415155; PMCID: PMC7769635. 3. Ding HS, Yang J, Yang J, Guo X, Tang YH, Huang Y, Chen Z, Fan ZX, Huang CX. Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway. Mol Biol Rep. 2021 May;48(5):3893-3901. doi: 10.1007/s11033-021-06326-9. Epub 2021 May 25. PMID: 34032975. 4. Yu JS, Shin DH, Kim JS. Repurposing of Fluvastatin as an Anticancer Agent against Breast Cancer Stem Cells via Encapsulation in a Hyaluronan-Conjugated Liposome. Pharmaceutics. 2020 Nov 24;12(12):1133. doi: 10.3390/pharmaceutics12121133. PMID: 33255298; PMCID: PMC7760927.
In vitro protocol:
1. Wang M, Wang J, Liu M, Chen G. Fluvastatin protects neuronal cells from hydrogen peroxide-induced toxicity with decreasing oxidative damage and increasing PI3K/Akt/mTOR signalling. J Pharm Pharmacol. 2021 Mar 8;73(4):515-521. doi: 10.1093/jpp/rgaa058. PMID: 33793833. 2. Zhao K, Tian Y, Wang J, Chen C, Pan B, Yan Z, Zhu S, Xu K. Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2. Biomed Res Int. 2020 Dec 19;2020:7619849. doi: 10.1155/2020/7619849. PMID: 33415155; PMCID: PMC7769635.
In vivo protocol:
1. Ding HS, Yang J, Yang J, Guo X, Tang YH, Huang Y, Chen Z, Fan ZX, Huang CX. Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway. Mol Biol Rep. 2021 May;48(5):3893-3901. doi: 10.1007/s11033-021-06326-9. Epub 2021 May 25. PMID: 34032975. 2. Yu JS, Shin DH, Kim JS. Repurposing of Fluvastatin as an Anticancer Agent against Breast Cancer Stem Cells via Encapsulation in a Hyaluronan-Conjugated Liposome. Pharmaceutics. 2020 Nov 24;12(12):1133. doi: 10.3390/pharmaceutics12121133. PMID: 33255298; PMCID: PMC7760927.
1: Mitani H, Kimura M. Preservation of endothelium-dependent and Nomega-nitro-L-arginine methyl ester- and indomethacin-resistant arterial relaxation in high-cholesterol-diet fed rabbits by treatment with fluvastatin, an HMG-CoA reductase inhibitor. J Cardiovasc Pharmacol. 2003 Jul;42(1):55-62. PubMed PMID: 12827027.