Synonym
Allylisopropylacetylurea; Apronal; Apronalide; Isodormid; Sedormid | Allylisopropylacetylcarbamide; (2-Isopropyl-4-pentenoyl)urea; N-Carbamoyl-2-isopropyl-4-pentenamide
IUPAC/Chemical Name
(2-Isopropyl-4-pentenoyl)urea
InChi Key
KSUUMAWCGDNLFK-UHFFFAOYSA-N
InChi Code
1S/C9H16N2O2/c1-4-5-7(6(2)3)8(12)11-9(10)13/h4,6-7H,1,5H2,2-3H3,(H3,10,11,12,13)
SMILES Code
C([C@@H](CC=C)C(C)C)(NC(N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
184.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hasegawa S, Hatahira H, Naganuma M, Shimauchi A, Sasaoka S, Motooka Y, Fukuda A, Abe J, Nakao S, Kato Y, Ohmori T, Iguchi K, Nakamura M. Adverse Event Trends Associated with OTC Analgesic and Antipyretic Drug: Data Mining of the Japanese Adverse Drug Event Report Database. Yakugaku Zasshi. 2017;137(10):1301-1311. doi: 10.1248/yakushi.17-00120. Japanese. PubMed PMID: 28966270.
2: Ueda T, Abe M, Okiyama R, Oyama S, Satoh K, Aiba S, Kaneko S, Katsuoka K. Acute generalized exanthematous pustulosis due to allylisopropylacetylurea: role of IL-17-producing T cells. Eur J Dermatol. 2011 Jan-Feb;21(1):140-1. doi: 10.1684/ejd.2010.1205. PubMed PMID: 21227897.
3: Ackroyd JF. Drug-induced thrombocytopenia. An immunological phenomenon. Vox Sang. 1983;45(3):257-9. PubMed PMID: 6684836.
4: Hackett T, Kelton JG, Powers P. Drug-induced platelet destruction. Semin Thromb Hemost. 1982 Apr;8(2):116-37. Review. PubMed PMID: 6805076.
5: ACKROYD JF. Purpura due to hypersensitivity to sedormid (allyl-isopropyl-acetyl-carbamide). Proc R Soc Med. 1953 Apr;46(4):261-3. PubMed PMID: 13055881.
6: JORON GE, DOWNING JB, BENSLEY EH. Fatal poisoning by sedormid (allyl-isopropyl-acetyl urea). Can Med Assoc J. 1953 Jan;68(1):62-3. PubMed PMID: 13019715; PubMed Central PMCID: PMC1822680.
