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MedKoo Cat#: 584729 | Name: PL 100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PL 100 inhibits HIV-1 protease.

Chemical Structure

PL 100
PL 100
CAS#612547-11-2

Theoretical Analysis

MedKoo Cat#: 584729

Name: PL 100

CAS#: 612547-11-2

Chemical Formula: C33H44N4O6S

Exact Mass: 624.2982

Molecular Weight: 624.80

Elemental Analysis: C, 63.44; H, 7.10; N, 8.97; O, 15.36; S, 5.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PL 100; PL-100; PPL 100; PPL-100; MK-8122; MX-100
IUPAC/Chemical Name
Methyl N-((1S)-1-(((5S)-5-((4-aminophenyl)sulfonyl-isobutyl-amino)-6-hydroxy-hexyl)carbamoyl)-2,2-diphenyl-ethyl)carbamate
InChi Key
QAHLFXYLXBBCPS-IZEXYCQBSA-N
InChi Code
InChI=1S/C33H44N4O6S/c1-24(2)22-37(44(41,42)29-19-17-27(34)18-20-29)28(23-38)16-10-11-21-35-32(39)31(36-33(40)43-3)30(25-12-6-4-7-13-25)26-14-8-5-9-15-26/h4-9,12-15,17-20,24,28,30-31,38H,10-11,16,21-23,34H2,1-3H3,(H,35,39)(H,36,40)/t28-,31-/m0/s1
SMILES Code
O=C(OC)N[C@H](C(NCCCC[C@H](N(S(=O)(C1=CC=C(N)C=C1)=O)CC(C)C)CO)=O)C(C2=CC=CC=C2)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 624.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 20541566. 4: Dandache S, Sévigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ. In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2007 Nov;51(11):4036-43. Epub 2007 Jul 16. PubMed PMID: 17638694; PubMed Central PMCID: PMC2151432. 5: Vuorinen EM, Rajala NK, Rauhala HE, Nurminen AT, Hytönen VP, Kallioniemi A. Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):211-219. doi: 10.1016/j.bbadis.2016.09.015. Epub 2016 Sep 21. PubMed PMID: 27664836. 6: Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setälä K. Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct. Cytotechnology. 2017 Oct;69(5):785-800. doi: 10.1007/s10616-017-0088-1. 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The effect of decompressive surgery on lumbar paraspinal and biceps brachii muscle function and movement perception in lumbar spinal stenosis: a 2-year follow-up. Eur Spine J. 2016 Mar;25(3):789-94. doi: 10.1007/s00586-015-4036-5. Epub 2015 May 27. PubMed PMID: 26014807. 17: Kärkkäinen JM, Lehtimäki TT, Manninen H, Paajanen H. Acute Mesenteric Ischemia Is a More Common Cause than Expected of Acute Abdomen in the Elderly. J Gastrointest Surg. 2015 Aug;19(8):1407-14. doi: 10.1007/s11605-015-2830-3. Epub 2015 Apr 28. PubMed PMID: 25917534. 18: Kärkkäinen JM, Miilunpohja S, Rantanen T, Koskela JM, Jyrkkä J, Hartikainen J, Paajanen H. Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding. Dig Dis Sci. 2015 Dec;60(12):3707-15. doi: 10.1007/s10620-015-3806-6. Epub 2015 Jul 16. PubMed PMID: 26177705. 19: Dubatolov VV, Zolotuhin VV, Witt TJ. Revision of Lithosia Fabricius, 1798 and Conilepia Hampson, 1900 (Lepidoptera, Arctiidae). 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SK&F 107260

SK&F 107260