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MedKoo Cat#: 564651 | Name: CMB4563

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CMB4563 is a potent ATP-competitive small molecule which preferentially inhibits the serine/threonine protein kinase target of rapamycin complex 2 (TORC2).

Chemical Structure

CMB4563
CMB4563
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564651

Name: CMB4563

CAS#: NONE

Chemical Formula: C26H19N5O

Exact Mass: 417.1590

Molecular Weight: 417.47

Elemental Analysis: C, 74.80; H, 4.59; N, 16.78; O, 3.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CMB-4563; CMB 4563; CMB4563
IUPAC/Chemical Name
1-(4-(1H-Pyrrol-1-yl)phenyl)-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
InChi Key
CQQZVRUJSYPEQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H19N5O/c1-29-24-17-28-23-11-6-18(19-5-4-12-27-16-19)15-22(23)25(24)31(26(29)32)21-9-7-20(8-10-21)30-13-2-3-14-30/h2-17H,1H3
SMILES Code
O=C(N1C2=CC=C(N3C=CC=C3)C=C2)N(C)C4=C1C5=CC(C6=CC=CN=C6)=CC=C5N=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R. Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae. J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12. PubMed PMID: 29895620; PubMed Central PMCID: PMC6078453.