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MedKoo Cat#: 573196 | Name: Aplysin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aplysin is an antineoplastic agent. Aplysin has been shown to suppress breast cancer cell activity via inhibition of the PI3K/AKT/FOXO3a pathway. Aplysin has also been shown to protect hepatocytes against oxidative damage.

Chemical Structure

Aplysin
Aplysin
CAS#6790-63-2

Theoretical Analysis

MedKoo Cat#: 573196

Name: Aplysin

CAS#: 6790-63-2

Chemical Formula: C15H19BrO

Exact Mass: 294.0619

Molecular Weight: 295.22

Elemental Analysis: C, 61.03; H, 6.49; Br, 27.07; O, 5.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Aplysin
IUPAC/Chemical Name
1H-Cyclopenta(b)benzofuran, 7-bromo-2,3,3a,8b-tetrahydro-3,3a,6,8b-tetramethyl-, (3S-(3alpha,3abeta,8bbeta))-
InChi Key
AZMIIVUEOLBHBL-LKTVYLICSA-N
InChi Code
1S/C15H19BrO/c1-9-7-13-11(8-12(9)16)14(3)6-5-10(2)15(14,4)17-13/h7-8,10H,5-6H2,1-4H3/t10-,14-,15-/m0/s1
SMILES Code
C[C@H]1CC[C@@]2(C)c3cc(Br)c(C)cc3O[C@@]12C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shakeel E, Sharma N, Akhtar S, Khan MKA, Lohani M, Siddiqui MH. Decoding the antineoplastic efficacy of Aplysin targeting Bcl-2: A de novo perspective. Comput Biol Chem. 2018 Dec;77:390-401. doi: 10.1016/j.compbiolchem.2018.09.003. Epub 2018 Sep 6. PubMed PMID: 30469054. 2: Ge N, Liang H, Zhao YY, Liu Y, Gong AJ, Zhang WL. Aplysin Protects Against Alcohol-Induced Liver Injury Via Alleviating Oxidative Damage and Modulating Endogenous Apoptosis-Related Genes Expression in Rats. J Food Sci. 2018 Oct;83(10):2612-2621. doi: 10.1111/1750-3841.14320. Epub 2018 Sep 7. PubMed PMID: 30192013. 3: Shakeel E, Akhtar S, Khan MKA, Lohani M, Arif JM, Siddiqui MH. Molecular docking analysis of aplysin analogs targeting survivin protein. Bioinformation. 2017 Sep 30;13(9):293-300. doi: 10.6026/97320630013293. eCollection 2017. PubMed PMID: 29081608; PubMed Central PMCID: PMC5651222. 4: Zhang X, Zhuang T, Liang Z, Li L, Xue M, Liu J, Liang H. Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway. Oncotarget. 2017 Jul 12;8(38):63923-63934. doi: 10.18632/oncotarget.19209. eCollection 2017 Sep 8. PubMed PMID: 28969041; PubMed Central PMCID: PMC5609973. 5: Xue M, Liu Y, Lyu R, Ge N, Liu M, Ma Y, Liang H. Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats. PLoS One. 2017 Jun 16;12(6):e0178684. doi: 10.1371/journal.pone.0178684. eCollection 2017. PubMed PMID: 28622357; PubMed Central PMCID: PMC5473570. 6: Gong AJ, Gong LL, Yao WC, Ge N, Lu LX, Liang H. Aplysin induces apoptosis in glioma cells through HSP90/AKT pathway. Exp Biol Med (Maywood). 2015 May;240(5):639-44. doi: 10.1177/1535370214555664. Epub 2014 Nov 6. PubMed PMID: 25377176; PubMed Central PMCID: PMC4935264. 7: Liu J, Ma L, Wu N, Liu G, Zheng L, Lin X. Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway. Mar Drugs. 2014 Sep 25;12(9):5072-88. doi: 10.3390/md12095072. PubMed PMID: 25257790; PubMed Central PMCID: PMC4178493. 8: Gong A, Ge N, Yao W, Lu L, Liang H. Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR-181 level. Cancer Chemother Pharmacol. 2014 Sep;74(3):531-8. doi: 10.1007/s00280-014-2534-5. Epub 2014 Jul 22. PubMed PMID: 25047724. 9: Ge N, Liang H, Liu Y, Ma AG, Han L. Protective effect of Aplysin on hepatic injury in ethanol-treated rats. Food Chem Toxicol. 2013 Dec;62:361-72. doi: 10.1016/j.fct.2013.08.071. Epub 2013 Aug 31. PubMed PMID: 24001440.