IUPAC/Chemical Name
Phenol, 2-(2-heptynylthio)-, acetate
InChi Key
GXMBHQRROXQUJS-UHFFFAOYSA-N
InChi Code
1S/C15H18O2S/c1-3-4-5-6-9-12-18-15-11-8-7-10-14(15)17-13(2)16/h7-8,10-11H,3-5,12H2,1-2H3
SMILES Code
c1c(c(ccc1)SCC#CCCCC)OC(C)=O
Appearance
A solution in methyl acetate
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
262.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Humar B, McNoe L, Dunbier A, Heathcott R, Braithwaite AW, Reeve AE. Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics. 2008 Jun;2(2):329-37. PubMed PMID: 19707365; PubMed Central PMCID: PMC2721360.
2: Pereira CF, Rutten K, Stránská R, Huigen MC, Aerts PC, de Groot RJ, Egberink HF, Schuurman R, Nottet HS. Spectrum of antiviral activity of o-(acetoxyphenyl)hept-2-ynyl sulphide (APHS). Int J Antimicrob Agents. 2005 May;25(5):419-26. PubMed PMID: 15848298.
3: Pereira CF, Paridaen JT, van de Bovenkamp M, Middel J, Verhoef J, Nottet HS. APHS can act synergically with clinically available HIV-1 reverse transcriptase and protease inhibitors and is active against several drug-resistant HIV-1 strains in vitro. J Antimicrob Chemother. 2003 May;51(5):1181-9. Epub 2003 Mar 28. PubMed PMID: 12668583.
4: Carlson NG. Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. J Neurosci Res. 2003 Jan 1;71(1):79-88. PubMed PMID: 12478616.
