Synonym
PF6683324; PF 6683324; PF-6683324; PF-06683324; PF 06683324; PF06683324
IUPAC/Chemical Name
2-(((3S,4R)-3-Fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide
InChi Key
XJIIVPVOGYFVME-AZUAARDMSA-N
InChi Code
InChI=1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m0/s1
SMILES Code
O=C(N)C1=C(O[C@H]2[C@@H](F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)N=CC(C4=CN(C)C=N4)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
521.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Qiu, L., Levine, K., Gajiwala, K. S., Cronin, C. N., Nagata, A., Johnson, E., ... & Sun, S. (2018). Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLoS One, 13(6), e0198374.
Jerin, S., Harvey, A. J., & Lewis, A. (2023). Therapeutic potential of protein tyrosine kinase 6 in colorectal cancer. Cancers, 15(14), 3703.
Ang, H. L., Yuan, Y., Lai, X., Tan, T. Z., Wang, L., Huang, B. B., ... & Kumar, A. P. (2021). Putting the BRK on breast cancer: From molecular target to therapeutics. Theranostics, 11(3), 1115.
