Synonym
APC-0576, APC0576
IUPAC/Chemical Name
Cyclopropanecarboxamide, N-(6-(4-((((1S)-2,2-dimethylcyclopropyl)carbonyl)amino)phenoxy)-3-pyridinyl)-2,2-dimethyl-, (1S)-
InChi Key
GABIPKHJFWRJQJ-QZTJIDSGSA-N
InChi Code
1S/C23H27N3O3/c1-22(2)11-17(22)20(27)25-14-5-8-16(9-6-14)29-19-10-7-15(13-24-19)26-21(28)18-12-23(18,3)4/h5-10,13,17-18H,11-12H2,1-4H3,(H,25,27)(H,26,28)/t17-,18-/m1/s1
SMILES Code
CC1(C[C@@H]1C(=O)Nc2ccc(cc2)Oc3ccc(cn3)NC(=O)[C@H]4CC4(C)C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
393.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Naruse S, Yamada J, Hamuro J, Kobayashi T, Mori K, Kinoshita S. APC0576 decreases production of pro-inflammatory chemokine and extracellular matrix by human Tenon's capsule fibroblasts. Exp Eye Res. 2004 Aug;79(2):223-30. PubMed PMID: 15325569.
2: Yuzawa K, Konishi A, Takehana K, Iino Y, Ohnuki A, Kobayashi T, Fukao K, Ohkohchi N. APC0576: a novel small molecule, immunosuppressive agent effective in primate models. Transplantation. 2003 May 15;75(9):1463-8. PubMed PMID: 12792498.
3: Takehana K, Konishi A, Oonuki A, Noguchi M, Fujita K, Iino Y, Kobayashi T. APC0576, a novel inhibitor of NF-kappaB-dependent gene activation, prevents pro-inflammatory cytokine-induced chemokine production in human endothelial cells. Biochem Biophys Res Commun. 2002 May 10;293(3):945-52. PubMed PMID: 12051750.
