MedKoo Cat#: 573191 | Name: Apaxifylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Apaxifylline is a selective Adenosine A1 antagonist.

Chemical Structure

Apaxifylline
Apaxifylline
CAS#151581-23-6

Theoretical Analysis

MedKoo Cat#: 573191

Name: Apaxifylline

CAS#: 151581-23-6

Chemical Formula: C16H22N4O3

Exact Mass: 318.1692

Molecular Weight: 318.38

Elemental Analysis: C, 60.36; H, 6.97; N, 17.60; O, 15.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Apaxifylline
IUPAC/Chemical Name
1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-, (S)-
InChi Key
RUHGOZFOVBMWOO-JTQLQIEISA-N
InChi Code
1S/C16H22N4O3/c1-3-7-19-14-12(15(22)20(8-4-2)16(19)23)17-13(18-14)10-5-6-11(21)9-10/h10H,3-9H2,1-2H3,(H,17,18)/t10-/m0/s1
SMILES Code
CCCn1c2c(c(=O)n(c1=O)CCC)[nH]c(n2)[C@H]3CCC(=O)C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou Y, Tong L, Chu X, Deng F, Tang J, Tang Y, Dai Y. The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. Cell Physiol Biochem. 2017;43(2):733-742. doi: 10.1159/000481557. Epub 2017 Sep 27. PubMed PMID: 28950257. 2: Dastjerdi MN, Rarani MZ, Valiani A, Mahmoudieh M. The effect of adenosine A1 receptor agonist and antagonist on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line. Res Pharm Sci. 2016 Jul;11(4):303-10. doi: 10.4103/1735-5362.189301. PubMed PMID: 27651810; PubMed Central PMCID: PMC5022378. 3: Zhai W, Chen D, Shen H, Chen Z, Li H, Yu Z, Chen G. A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway. Mol Brain. 2016 Jun 14;9(1):66. doi: 10.1186/s13041-016-0247-x. PubMed PMID: 27301321; PubMed Central PMCID: PMC4908780. 4: Dastjerdi MN, Valiani A, Mardani M, Ra MZ. Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7. Bratisl Lek Listy. 2016;117(4):242-6. PubMed PMID: 27075390. 5: Searl TJ, Dynda DI, Alanee SR, El-Zawahry AM, McVary KT, Silinsky EM. A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder. J Pharmacol Exp Ther. 2016 Jan;356(1):116-22. doi: 10.1124/jpet.115.228882. Epub 2015 Nov 3. PubMed PMID: 26534943; PubMed Central PMCID: PMC4702072. 6: Kusek J, Yang Q, Witek M, Gruber CW, Nanoff C, Freissmuth M. Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept. Mol Pharmacol. 2015 Jan;87(1):39-51. doi: 10.1124/mol.114.094045. Epub 2014 Oct 29. PubMed PMID: 25354767; PubMed Central PMCID: PMC4513639. 7: Nascimento FP, Macedo-Júnior SJ, Pamplona FA, Luiz-Cerutti M, Córdova MM, Constantino L, Tasca CI, Dutra RC, Calixto JB, Reid A, Sawynok J, Santos AR. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78. doi: 10.1007/s12035-014-8815-5. Epub 2014 Jul 27. PubMed PMID: 25064055.