IBE-667 is an ICAM-1 binding enhancer for LFA-1. Cellular assays demonstrate the activity of IBE-667 in promoting the binding of LFA-1 on activated immune cells to ICAM-1. IBE-667 increases the binding of biotinylated soluble ICAM-1 to activated T-cells as determined by staining with PE-streptavidin and FACS analysis. IBE-667 leads to a concentration dependent induction of T-cell aggregation after activation by anti CD3 and anti CD28 antibodies. IBE-667 induced T-cell aggregation can be completely reversed with an LFA-1 neutralizing antibody.
MedKoo Cat#: 564624
Name: IBE-667
CAS#: 1609659-32-6
Chemical Formula: C25H25N5O2
Exact Mass: 427.2008
Molecular Weight: 427.51
Elemental Analysis: C, 70.24; H, 5.89; N, 16.38; O, 7.48
The following data is based on the product molecular weight 427.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
