LY6 is a potent and selective SHP2 inhibitor. LY6 inhibited SHP2 with an IC50 value of 9.8 μM, 7-fold more selective for SHP2 than the highly related SHP1. Fluorescence titration, thermal shift, and microscale thermophoresis quantitative binding assays confirmed its direct binding to SHP2. LY6 has a potential to serve as a lead compound for further optimization studies to develop novel anti-SHP2 therapeutic agents.
MedKoo Cat#: 4101001
Name: LY6
CAS#: Unknown
Chemical Formula: C30H27Cl2N3O4
Exact Mass: 563.1379
Molecular Weight: 564.46
Elemental Analysis: C, 63.84; H, 4.82; Cl, 12.56; N, 7.44; O, 11.34
The following data is based on the product molecular weight 564.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
