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MedKoo Cat#: 564568 | Name: EMDB-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EMDB-3 is a peptide endomorphin (EM) degradation blocker.

Chemical Structure

EMDB-3
EMDB-3
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564568

Name: EMDB-3

CAS#: NONE

Chemical Formula: C17H23N3O5

Exact Mass: 349.1638

Molecular Weight: 349.39

Elemental Analysis: C, 58.44; H, 6.64; N, 12.03; O, 22.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EMDB3; EMDB 3; EMDB-3
IUPAC/Chemical Name
Tyr-Pro-Ala-OH, L-Tyrosyl-L-prolyl-L-alanine
InChi Key
CDBXVDXSLPLFMD-BPNCWPANSA-N
InChi Code
InChI=1S/C17H23N3O5/c1-10(17(24)25)19-15(22)14-3-2-8-20(14)16(23)13(18)9-11-4-6-12(21)7-5-11/h4-7,10,13-14,21H,2-3,8-9,18H2,1H3,(H,19,22)(H,24,25)/t10-,13-,14-/m0/s1
SMILES Code
O=C(N1[C@@H](CCC1)C(N[C@@H](C)C(O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Perlikowska R, Fichna J, do-Rego JC, Gach K, Janecka A. Kinetic studies of novel inhibitors of endomorphin degrading enzymes. Med Chem Res. 2012 Jul;21(7):1445-1450. Epub 2011 May 20. PubMed PMID: 22707871; PubMed Central PMCID: PMC3359464. 2: Fichna J, Perlikowska R, Gach K, do-Rego JC, Cravezic A, Janecka A, Storr MA. The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro. Chem Biol Drug Des. 2010 Jul;76(1):77-81. doi: 10.1111/j.1747-0285.2010.00977.x. Epub 2010 Apr 23. PubMed PMID: 20456368.

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