Synonym
Meobentine; Meobentina; Meobentinum
IUPAC/Chemical Name
Guanidine, N-((4-methoxyphenyl)methyl)-N',N''-dimethyl-
InChi Key
SPLVKBMIQSSFFN-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17N3O/c1-12-11(13-2)14-8-9-4-6-10(15-3)7-5-9/h4-7H,8H2,1-3H3,(H2,12,13,14)
SMILES Code
C/N=C(NC)/NCC1=CC=C(OC)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
207.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Warren JT, Coker GG, Welch RM, Fowle AS, Findlay JW. Plasma levels of a novel antidysrhythmic agent, meobentine sulfate, in humans as determined by radioimmunoassay. J Pharm Sci. 1982 Jun;71(6):665-70. PubMed PMID: 7097530.
2: Northover BJ. A comparison of the effects of bethanidine, meobentine and quinidine on the electrical activity of rat hearts in vivo and in vitro. Br J Pharmacol. 1985 Mar;84(3):755-63. PubMed PMID: 3986433; PubMed Central PMCID: PMC1987150.
3: Anderson JL, Reid PR, Platia EV, Akhtar M, Ruskin JN, Schaal SF, Jueng P, Long RA, Wenger TL. Meobentine sulfate: antiarrhythmic and electrophysiologic effects assessed by programmed electrical stimulation and ambulatory monitoring in patients with complex ventricular tachyarrhythmia. Report of a multicenter evaluation. Am Heart J. 1985 Oct;110(4):774-84. PubMed PMID: 3901715.
4: Duff HJ, Oates JA, Roden DM, Woosley RL. The antiarrhythmic activity of meobentine sulfate in man. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):650-6. PubMed PMID: 6206320.
5: Zimmerman JM, Patterson E, Pitt B, Lucchesi B. Antidysrhythmic actions of meobentine sulfate. Am Heart J. 1984 Jun;107(6):1117-24. PubMed PMID: 6720538.
6: Dangman KH, Wang HH, Reynolds RD. Studies on bethanidine and meobentine: direct and indirect effects of antifibrillatory drugs. J Cardiovasc Pharmacol. 1986 Nov-Dec;8(6):1185-94. PubMed PMID: 2434745.
7: Wastila WB, Copp FC, Walton E, Ellis CH, Maxwell RA. Meobentine sulphate (bis[N-4-methoxybenzyl-N'N"-dimethylguanidine]sulphate): a new antidysrhythmic agent. J Pharm Pharmacol. 1981 Sep;33(9):594-6. PubMed PMID: 6117639.
8: Bacaner MB, Clay JR, Shrier A, Brochu RM. Potassium channel blockade: A mechanism for suppressing ventricular fibrillation. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2223-7. PubMed PMID: 2421289; PubMed Central PMCID: PMC323264.
