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MedKoo Cat#: 584707 | Name: Mefway F-18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mefway F-18 is a PET radioligand specific to serotonin-1A receptors.

Chemical Structure

Mefway F-18
Mefway F-18
CAS#943962-60-5

Theoretical Analysis

MedKoo Cat#: 584707

Name: Mefway F-18

CAS#: 943962-60-5

Chemical Formula: C26H3518FN4O2

Exact Mass: 453.2769

Molecular Weight: 453.59

Elemental Analysis: C, 68.85; H, 7.78; F, 3.97; N, 12.35; O, 7.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Mefway F-18; 18F-Mefway
IUPAC/Chemical Name
Cyclohexanecarboxamide, 4-(fluoro-18f-methyl)-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-
InChi Key
BQGLPDFQLBNUGU-FMLNDMEQSA-N
InChi Code
InChI=1S/C26H35FN4O2/c1-33-24-7-3-2-6-23(24)30-17-14-29(15-18-30)16-19-31(25-8-4-5-13-28-25)26(32)22-11-9-21(20-27)10-12-22/h2-8,13,21-22H,9-12,14-20H2,1H3/i27-1
SMILES Code
O=C(C1CCC(C[18F])CC1)N(CCN2CCN(C3=CC=CC=C3OC)CC2)C4=NC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Choi JY, Lyoo CH, Kim JS, Kim KM, Lee M, Ryu YH. Biodistribution and Radiation Dosimetry of [(18)F]Mefway in Humans. Mol Imaging Biol. 2016 Dec;18(6):803-806. PubMed PMID: 27126460. 2: Choi JY, Lyoo CH, Kim JS, Kim KM, Kang JH, Choi SH, Kim JJ, Ryu YH. 18F-Mefway PET imaging of serotonin 1A receptors in humans: a comparison with 18F-FCWAY. PLoS One. 2015 Apr 1;10(4):e0121342. doi: 10.1371/journal.pone.0121342. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127491. PubMed PMID: 25830772; PubMed Central PMCID: PMC4382022. 3: Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. Am J Nucl Med Mol Imaging. 2014 Aug 15;4(5):483-9. eCollection 2014. PubMed PMID: 25143866; PubMed Central PMCID: PMC4138142. 4: Mukherjee J, Bajwa AK, Wooten DW, Hillmer AT, Pan ML, Pandey SK, Saigal N, Christian BT. Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans. J Comp Neurol. 2016 May 1;524(7):1457-71. doi: 10.1002/cne.23919. Epub 2015 Nov 18. PubMed PMID: 26509362; PubMed Central PMCID: PMC4783179. 5: Saigal N, Bajwa AK, Faheem SS, Coleman RA, Pandey SK, Constantinescu CC, Fong V, Mukherjee J. Evaluation of serotonin 5-HT(1A) receptors in rodent models using [¹⁸F]mefway PET. Synapse. 2013 Sep;67(9):596-608. doi: 10.1002/syn.21665. Epub 2013 Apr 18. PubMed PMID: 23504990; PubMed Central PMCID: PMC3744326. 6: Thio JP, Liang C, Bajwa AK, Wooten DW, Christian BT, Mukherjee J. Synthesis and Evaluation of Mefway Analogs as Ligands for Serotonin 5HT(1A) Receptors. Med Chem Res. 2015 Apr;24(4):1480-1486. PubMed PMID: 25750500; PubMed Central PMCID: PMC4349336. 7: Constantinescu CC, Sevrioukov E, Garcia A, Pan ML, Mukherjee J. Evaluation of [18F]Mefway biodistribution and dosimetry based on whole-body PET imaging of mice. Mol Imaging Biol. 2013 Apr;15(2):222-9. doi: 10.1007/s11307-012-0582-y. PubMed PMID: 22833323; PubMed Central PMCID: PMC3808848. 8: Lee JH, Ryu YH, Lyoo CH, Choi SH, Kim JJ, Choi JY. Optimal timing of [¹⁸F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects. Appl Radiat Isot. 2016 Jan;107:127-132. doi: 10.1016/j.apradiso.2015.10.004. Epub 2015 Oct 9. PubMed PMID: 26492323. 9: Hillmer AT, Wooten DW, Bajwa AK, Higgins AT, Lao PJ, Betthauser TJ, Barnhart TE, Rowley HA, Stone CK, Johnson SC, Mukherjee J, Christian BT. First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors. J Nucl Med. 2014 Dec;55(12):1973-9. doi: 10.2967/jnumed.114.145151. Epub 2014 Nov 13. PubMed PMID: 25453045; PubMed Central PMCID: PMC4316674. 10: Wooten DW, Moraino JD, Hillmer AT, Engle JW, Dejesus OJ, Murali D, Barnhart TE, Nickles RJ, Davidson RJ, Schneider ML, Mukherjee J, Christian BT. In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate. Synapse. 2011 Jul;65(7):592-600. doi: 10.1002/syn.20878. Epub 2010 Dec 8. PubMed PMID: 21484878; PubMed Central PMCID: PMC3080024. 11: Choi JY, Song JS, Lee M, Cho WK, Chung J, Lyoo CH, Kim CH, Park J, Lee KC, Kim KM, Kang JH, Bae MA, Ryu YH. P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain. Mol Imaging Biol. 2016 Apr;18(2):267-73. doi: 10.1007/s11307-015-0883-z. PubMed PMID: 26250653. 12: Wooten DW, Hillmer AT, Moirano JM, Ahlers EO, Slesarev M, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [(18)F]mefway in the nonhuman primate. J Cereb Blood Flow Metab. 2012 Aug;32(8):1546-58. doi: 10.1038/jcbfm.2012.43. Epub 2012 Apr 4. PubMed PMID: 22472611; PubMed Central PMCID: PMC3421091. 13: Wooten D, Hillmer A, Murali D, Barnhart T, Schneider ML, Mukherjee J, Christian BT. An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate. Nucl Med Biol. 2011 Oct;38(7):925-32. doi: 10.1016/j.nucmedbio.2011.04.001. Epub 2011 Jul 7. PubMed PMID: 21741252; PubMed Central PMCID: PMC3190069. 14: Choi JY, Kim BS, Kim CH, Kim DG, Han SJ, Lee K, Kim KM, An G, Choi TH, Yoo SD, Ryu YH. Translational possibility of [(18) F]Mefway to image serotonin 1A receptors in humans: Comparison with [(18) F]FCWAY in rodents. Synapse. 2014 Dec;68(12):595-603. doi: 10.1002/syn.21771. Epub 2014 Jul 31. PubMed PMID: 25056144. 15: Choi JY, Lyoo CH, Kim JS, Kim KM, Kang JH, Choi SH, Kim JJ, Ryu YH. Correction: 18F-Mefway PET Imaging of Serotonin 1A Receptors in Humans: A Comparison with 18F-FCWAY. PLoS One. 2015 Apr 27;10(4):e0127491. doi: 10.1371/journal.pone.0127491. eCollection 2015. PubMed PMID: 25915858; PubMed Central PMCID: PMC4411173. 16: Lee M, Ryu YH, Cho WG, Jeon TJ, Lyoo CH, Kang YW, Lee SJ, Kim CH, Kim DG, Kang JH, Seo YB, Yi CH, Lee K, Choi TH, Choi JY. Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[(18)F]Mefway. Appl Radiat Isot. 2014 Dec;94:30-34. doi: 10.1016/j.apradiso.2014.06.016. Epub 2014 Jul 8. PubMed PMID: 25064461. 17: Choi JY, Kim CH, Jeon TJ, Kim BS, Yi CH, Woo KS, Seo YB, Han SJ, Kim KM, Yi DI, Lee M, Kim DG, Kim JY, Lee KC, Choi TH, An G, Ryu YH. Effective microPET imaging of brain 5-HT(1A) receptors in rats with [(18) F]MeFWAY by suppression of radioligand defluorination. Synapse. 2012 Dec;66(12):1015-23. doi: 10.1002/syn.21607. Epub 2012 Sep 29. PubMed PMID: 22927318. 18: Wooten DW, Hillmer AT, Moirano JM, Tudorascu DL, Ahlers EO, Slesarev MS, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. 5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate. Neuroimage. 2013 Aug 15;77:125-32. doi: 10.1016/j.neuroimage.2013.03.027. Epub 2013 Mar 26. PubMed PMID: 23537936; PubMed Central PMCID: PMC3654069. 19: Choi JY, Kim CH, Ryu YH, Seo YB, Truong P, Kim EJ, Choi TH, Kang J, Lee M, Kim DG, Lee JD, Jeon TJ. Optimization of the radiosynthesis of [(18) F]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module. J Labelled Comp Radiopharm. 2013 Oct;56(12):589-94. doi: 10.1002/jlcr.3067. Epub 2013 Jun 28. PubMed PMID: 24285234. 20: Saigal N, Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J. Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate. J Nucl Med. 2006 Oct;47(10):1697-706. PubMed PMID: 17015907.

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