Synonym
FDL169; FDL-169; FDL 169;
IUPAC/Chemical Name
2-(7-ethoxy-4-(3-fluorophenyl)-1-oxophthalazin-2(1h)-yl)-n-methyl-n-(2-methylbenzo[d]oxazol-6-yl)acetamide
InChi Key
XRPSUWYWZUQALB-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H23FN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
SMILES Code
O=C(N(C)C1=CC=C2N=C(C)OC2=C1)CN(N=C(C3=CC=CC(F)=C3)C4=C5C=C(OCC)C=C4)C5=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
33.0 |
67.83 |
| Ethanol |
8.0 |
16.44 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
486.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
WS18. 1 Combination FDL169/FDL176 is superior to tezacaftor/ivacaftor B Cole, P Bhatt, I Kwok, V Bailey, W An… - Journal of Cystic …, 2017 - cysticfibrosisjournal.com
EFFECT OF NOVEL F508DEL-CFTR MODULATOR COMBINATION FDL169 AND FDL176 ON EXPRESSION AND FUNCTIONAL ACTIVITY I Kwok, L Miranda, P Bhatt, V Bailey… - PEDIATRIC …, 2016 - flatleydiscoverylab.com
P022 Safety, tolerability and pharmacokinetics of CFTR corrector FDL169 CL Ordonez, A Horsley, J Chai, AF Kolodziej… - Journal of Cystic …, 2018 - Elsevier
NOVEL CFTR CORRECTOR FDL169: SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS AR Horsley, S Blaas, L Burr… - PEDIATRIC …, 2018 - … ST, HOBOKEN 07030-5774, NJ USA
