DEAP fluoranthene, interaction with DNA and metaphase chromosomes by bind to DNA. DEAP fluoranthene shows a slight A-T preference in binding to DNA and was also found to change the topological winding number of superhelical DNA. These data, and the determined unwinding angle of 27 degree for DEAP fluoranthene, strongly support an intercalation mode of binding for this drug to DNA.
MedKoo Cat#: 681634
Name: DEAP fluoranthene
CAS#: 27086-86-8
Chemical Formula: C32H42Cl2N2O4
Exact Mass: 588.2522
Molecular Weight: 589.60
Elemental Analysis: C, 65.19; H, 7.18; Cl, 12.03; N, 4.75; O, 10.85
The following data is based on the product molecular weight 589.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
