MedKoo Cat#: 584702 | Name: Afidopyropen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Afidopyropen is a TRPV channel modulator with insecticidal activity.

Chemical Structure

Afidopyropen
Afidopyropen
CAS#915972-17-7

Theoretical Analysis

MedKoo Cat#: 584702

Name: Afidopyropen

CAS#: 915972-17-7

Chemical Formula: C33H39NO9

Exact Mass: 593.2625

Molecular Weight: 593.67

Elemental Analysis: C, 66.76; H, 6.62; N, 2.36; O, 24.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Afidopyropen; ME-5343
IUPAC/Chemical Name
Cyclopropanecarboxylic acid, ((3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-((cyclopropylcarbonyl)oxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(3-pyridinyl)-2H,11H-naphtho(2,1-b)pyrano(3,4-E)pyran-4-yl)methyl ester
InChi Key
LRZWFURXIMFONG-HRSIRGMGSA-N
InChi Code
InChI=1S/C33H39NO9/c1-31-11-10-24(42-29(38)18-8-9-18)32(2,16-40-28(37)17-6-7-17)22(31)14-23(35)33(3)27(31)26(36)25-21(43-33)13-20(41-30(25)39)19-5-4-12-34-15-19/h4-5,12-13,15,17-18,22-24,26-27,35-36H,6-11,14,16H2,1-3H3/t22-,23+,24+,26+,27-,31+,32+,33-/m1/s1
SMILES Code
O=C(C1CC1)OC[C@@]([C@@H](OC(C2CC2)=O)CC[C@@]34C)(C)[C@]3([H])C[C@H](O)[C@]5(C)[C@]4([H])[C@@H](O)C(C6=O)=C(C=C(C7=CC=CN=C7)O6)O5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 593.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kandasamy R, London D, Stam L, von Deyn W, Zhao X, Salgado VL, Nesterov A. Afidopyropen: New and potent modulator of insect transient receptor potential channels. Insect Biochem Mol Biol. 2017 May;84:32-39. doi: 10.1016/j.ibmb.2017.03.005. Epub 2017 Mar 24. PubMed PMID: 28347703. 2: Chen Y, Guo M, Liu X, Xu J, Dong F, Wu X, Li B, Zheng Y. Determination and dissipation of afidopyropen and its metabolite in wheat and soil using QuEChERS-UHPLC-MS/MS. J Sep Sci. 2018 Apr;41(7):1674-1681. doi: 10.1002/jssc.201700773. Epub 2018 Jan 26. PubMed PMID: 29280287. 3: Chen K, Liu X, Wu X, Dong F, Xu J, Zheng Y. Simultaneous determination of afidopyropen and its metabolite in vegetables, fruit and soil using UHPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Apr;35(4):715-722. doi: 10.1080/19440049.2017.1421777. Epub 2018 Jan 17. PubMed PMID: 29338668. 4: Van Cott A, Frericks M, Hastings C, Honarvar N, Flick B, Fabian E, van Ravenzwaay B. Uterine adenocarcinoma in the rat induced by afidopyropen. An analysis of the lesion's induction, progression and its relevance to humans. Regul Toxicol Pharmacol. 2018 Jun;95:29-51. doi: 10.1016/j.yrtph.2018.02.018. Epub 2018 Mar 3. PubMed PMID: 29510166.