MedKoo Cat#: 581631 | Name: Deanxit

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deanxit contains melitracen & flupenthixol. It has antidepressant properties.

Chemical Structure

 Deanxit
Deanxit
CAS# 76391-77-0

Theoretical Analysis

MedKoo Cat#: 581631

Name: Deanxit

CAS#: 76391-77-0

Chemical Formula: C44H50F3N3OS

Exact Mass: 725.3627

Molecular Weight: 725.96

Elemental Analysis: C, 72.80; H, 6.94; F, 7.85; N, 5.79; O, 2.20; S, 4.42

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Deanxit; Placida; Franxit; Anxidreg; Danxipress.
IUPAC/Chemical Name
(E)-2-(4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethan-1-ol compound with 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine (1:1)
InChi Key
NECXFGBJNUZGBH-RZFZGDDESA-N
InChi Code
InChI=1S/C23H25F3N2OS.C21H25N/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h1-2,4-8,16,29H,3,9-15H2;5-8,10-14H,9,15H2,1-4H3/b18-5+;
SMILES Code
N1(CCO)CCN(CC\C=C2\c3cc(ccc3Sc3ccccc23)C(F)(F)F)CC1.C(C\C=C1\c2ccccc2C(c2ccccc12)(C)C)N(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 725.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Effect of clinician-patient communication on compliance with flupentixol-melitracen in functional dyspepsia patients. World J Gastroenterol. 2015 Apr 21;21(15):4652-9. doi: 10.3748/wjg.v21.i15.4652. PubMed PMID: 25914475; PubMed Central PMCID: PMC4402313. 9: Ma XJ, Zhao J, Feng ZY, Chang JM, Meng S, Liu HZ, Fan KF. [Effects of modified Ganmai Dazao decoction on neuroendocrine system in patients with climacteric depression]. Zhongguo Zhong Yao Za Zhi. 2014 Dec;39(23):4680-4. Chinese. PubMed PMID: 25911823. 10: Yu X, Zhang X, Liu X. [Efficacy on somatoform pain disorder treated with resuscitation and tranquilization acupuncture technique]. Zhongguo Zhen Jiu. 2015 Jan;35(1):25-9. Chinese. PubMed PMID: 25906561. 11: Wang L, Zhong Z, Hu J, Rong X, Liu J, Xiao S, Liu Z. Sertraline plus deanxit to treat patients with depression and anxiety in chronic somatic diseases: a randomized controlled trial. BMC Psychiatry. 2015 Apr 14;15:84. doi: 10.1186/s12888-015-0449-2. PubMed PMID: 25879863; PubMed Central PMCID: PMC4403889. 12: Zheng JR, Xie YM. [HIS-based analysis of comorbid characteristics and combined treatment of Chinese and western medicine in patients with depressive disorder]. Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(18):3454-61. Chinese. PubMed PMID: 25532377. 13: Yu YY, Fang DC, Fan LL, Chang H, Wu ZL, Cao Y, Lan CH. Efficacy and safety of esomeprazole with flupentixol/melitracen in treating gastroesophageal reflux disease patients with emotional disorders. J Gastroenterol Hepatol. 2014 Jun;29(6):1200-6. PubMed PMID: 24955450. 14: Peng L, Zhang X, Kang DY, Liu XT, Hong Q. Effectiveness and safety of Wuling capsule for post stroke depression: a systematic review. Complement Ther Med. 2014 Jun;22(3):549-66. doi: 10.1016/j.ctim.2014.04.005. Epub 2014 May 6. Review. PubMed PMID: 24906594. 15: Liu EJ, Zhang WL, Bai YP. [Observation on clinical efficacy of depression treated with the alliance of acupuncture and medication]. Zhongguo Zhen Jiu. 2013 Jun;33(6):497-500. Chinese. PubMed PMID: 23967634. 16: Lu LL, Shen XH, Chen JX. [Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):638-40. Chinese. PubMed PMID: 23905383. 17: Zhang Y, Becker T, Kösters M. Preliminary study of patterns of medication use for depression treatment in China. Asia Pac Psychiatry. 2013 Dec;5(4):231-6. doi: 10.1111/appy.12022. Epub 2012 Dec 20. Review. PubMed PMID: 23857675. 18: Cao H, Ju K, Zhong L, Meng T. Efficacy of hyperbaric oxygen treatment for depression in the convalescent stage following cerebral hemorrhage. Exp Ther Med. 2013 Jun;5(6):1609-1612. Epub 2013 Apr 2. PubMed PMID: 23837040; PubMed Central PMCID: PMC3702722. 19: Bhaumik S. India's health ministry bans pioglitazone, metamizole, and flupentixol-melitracen. BMJ. 2013 Jul 5;347:f4366. doi: 10.1136/bmj.f4366. Erratum in: BMJ. 2015;350:h1232. PubMed PMID: 23833116. 20: Chen YH, Chen XK, Yin XJ. [Comparison of the therapeutic effects of electroacupuncture and probiotics combined with deanxit in treating diarrhea-predominant irritable bowel syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 May;32(5):594-8. Chinese. PubMed PMID: 22679715.