MedKoo Cat#: 584697 | Name: Tropapride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tropapride is a benzamide derivative.

Chemical Structure

Tropapride
Tropapride
CAS#76352-13-1

Theoretical Analysis

MedKoo Cat#: 584697

Name: Tropapride

CAS#: 76352-13-1

Chemical Formula: C23H28N2O3

Exact Mass: 380.2100

Molecular Weight: 380.49

Elemental Analysis: C, 72.60; H, 7.42; N, 7.36; O, 12.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Tropapride
IUPAC/Chemical Name
Benzamide, 2,3-dimethoxy-N-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-
InChi Key
PCIWCYUKRZFCMF-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H28N2O3/c1-27-21-10-6-9-20(22(21)28-2)23(26)24-17-13-18-11-12-19(14-17)25(18)15-16-7-4-3-5-8-16/h3-10,17-19H,11-15H2,1-2H3,(H,24,26)
SMILES Code
O=C(NC1CC(N2CC3=CC=CC=C3)CCC2C1)C4=CC=CC(OC)=C4OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 380.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Strolin Benedetti M, Dow J, Dostert S, Parisy D, Rumigny JF. Localization of a new benzamide derivative, tropapride and of 1-sulpiride, in the pituitary gland of the rat. J Pharmacol. 1984 Oct-Dec;15(4):433-8. PubMed PMID: 6543239. 2: Collin S, Vercauteren DP, Vanderveken D, Evrard G, Durant F. Structural requirements of Na+-dependent antidopaminergic agents: Tropapride, Piquindone, Zetidoline, and Metoclopramide. Comparison with Na+-independent ligands. J Comput Aided Mol Des. 1989 Mar;3(1):39-53. PubMed PMID: 2715795. 3: Damhaut P, Cantineau R, Lemaire C, Plenevaux A, Christiaens L, Guillaume M. 2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies. Int J Rad Appl Instrum A. 1992 Oct;43(10):1265-74. PubMed PMID: 1330979. 4: Rumigny JF, Strolin Benedetti M, Dostert P. Investigation on central dopaminergic receptors (D-2) using the antagonistic properties of new benzamides. J Pharm Pharmacol. 1984 Jun;36(6):373-7. PubMed PMID: 6146667. 5: Wurch T, Boutet-Robinet EA, Palmier C, Colpaert FC, Pauwels PJ. Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs. J Pharmacol Exp Ther. 2003 Jan;304(1):380-90. PubMed PMID: 12490615. 6: Prinssen EP, Kleven MS, Koek W. Interactions between neuroleptics and 5-HT(1A) ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects. Psychopharmacology (Berl). 1999 May;144(1):20-9. PubMed PMID: 10379620. 7: Pauwels PJ, Koek W. Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan;365(1):82-5. Epub 2001 Oct 31. PubMed PMID: 11862337. 8: Jalfre M, Bucher B, Dorme N, Mocquet G, Porsolt RD. Neuropharmacological profile of MD 790501, a new benzamide derivative. Arch Int Pharmacodyn Ther. 1983 Aug;264(2):232-56. PubMed PMID: 6139097. 9: Pauwels PJ, Finana F, Tardif S, Wurch T, Colpaert FC. Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states. J Pharmacol Exp Ther. 2001 Apr;297(1):133-40. PubMed PMID: 11259537.