Synonym
Momordicin I; Momordicine I
IUPAC/Chemical Name
(3S,7S,8S,9R,10R,13R,14S,17R)-3,7-dihydroxy-17-[(2R)-4-hydroxy-6-methylhept-5-en-2-yl]-4,4,13,14-tetramethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-9-carbaldehyde
InChi Key
QBXNBPFTVLJTMK-KIAXAHKRSA-N
InChi Code
InChI=1S/C30H48O4/c1-18(2)14-20(32)15-19(3)21-10-11-29(7)26-24(33)16-23-22(8-9-25(34)27(23,4)5)30(26,17-31)13-12-28(21,29)6/h14,16-17,19-22,24-26,32-34H,8-13,15H2,1-7H3/t19-,20?,21-,22-,24+,25+,26+,28-,29+,30-/m1/s1
SMILES Code
O=C[C@@]12CC[C@]3(C)[C@@H]([C@@H](CC(O)/C=C(C)\C)C)CC[C@@]3(C)[C@]1([H])[C@@H](O)C=C4C(C)(C)[C@@H](O)CC[C@@]24[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Momordicine I is a secondary metabolite from bitter melon (Momordica charantia L.) which significantly inhibits Spodoptera litura ovary cell line (SL-1 cell) proliferation.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
472.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Chen PY, Shih NL, Hao WR, Chen CC, Liu JC, Sung LC. Inhibitory Effects of Momordicine I on High-Glucose-Induced Cell Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts. Oxid Med Cell Longev. 2018 Oct 8;2018:3939714. doi: 10.1155/2018/3939714. eCollection 2018. PubMed PMID: 30402205; PubMed Central PMCID: PMC6196925.
2: Liu H, Wang GC, Zhang MX, Ling B. The cytotoxicology of momordicins I and II on Spodoptera litura cultured cell line SL-1. Pestic Biochem Physiol. 2015 Jul;122:110-8. doi: 10.1016/j.pestbp.2014.12.007. Epub 2014 Dec 15. PubMed PMID: 26071815.
3: Wu SB, Yue GG, To MH, Keller AC, Lau CB, Kennelly EJ. Transport in Caco-2 cell monolayers of antidiabetic cucurbitane triterpenoids from Momordica charantia fruits. Planta Med. 2014 Jul;80(11):907-11. doi: 10.1055/s-0034-1382837. Epub 2014 Aug 12. PubMed PMID: 25116119.
4: Keller AC, Ma J, Kavalier A, He K, Brillantes AM, Kennelly EJ. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine. 2011 Dec 15;19(1):32-7. doi: 10.1016/j.phymed.2011.06.019. Epub 2011 Nov 30. PubMed PMID: 22133295; PubMed Central PMCID: PMC3389550.
5: Ma J, Whittaker P, Keller AC, Mazzola EP, Pawar RS, White KD, Callahan JH, Kennelly EJ, Krynitsky AJ, Rader JI. Cucurbitane-type triterpenoids from Momordica charantia. Planta Med. 2010 Oct;76(15):1758-61. doi: 10.1055/s-0030-1249807. Epub 2010 Apr 8. Erratum in: Planta Med. 2012 Jan;78(1):102. PubMed PMID: 20379957.
6: Chen J, Tian R, Qiu M, Lu L, Zheng Y, Zhang Z. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry. 2008 Feb;69(4):1043-8. Epub 2007 Nov 28. PubMed PMID: 18045630.
