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MedKoo Cat#: 564506 | Name: SPI-1865

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPI-1865 is a gamma-secretase modulator.

Chemical Structure

SPI-1865
SPI-1865
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564506

Name: SPI-1865

CAS#: NONE

Chemical Formula: C42H72N2O6

Exact Mass: 700.5390

Molecular Weight: 701.05

Elemental Analysis: C, 71.96; H, 10.35; N, 4.00; O, 13.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SPI1865; SPI 1865; SPI-1865
IUPAC/Chemical Name
(2aR,4S,6aR,7aS,9aR,9bR,10R,12R,13aR,14R,14aS,14bR)-12-((S)-1-Ethoxy-2-hydroxy-2-methylpropyl)-4-(((S)-4-(1-isopropylazetidin-3-yl)morpholin-2-yl)oxy)-3,3,9a,10,14a-pentamethyloctadecahydro-7H-cyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]pyran-14-ol
InChi Key
ITAXZEXGQGVKHD-QWBCZVDJSA-N
InChi Code
InChI=1S/C42H72N2O6/c1-11-47-36(38(7,8)46)28-20-26(4)33-34(49-28)35(45)40(10)30-13-12-29-37(5,6)31(14-15-41(29)24-42(30,41)17-16-39(33,40)9)50-32-23-43(18-19-48-32)27-21-44(22-27)25(2)3/h25-36,45-46H,11-24H2,1-10H3/t26-,28-,29+,30+,31+,32+,33+,34-,35+,36+,39-,40-,41-,42+/m1/s1
SMILES Code
O[C@@H]1[C@@]2(C)[C@@](CC[C@@]3([H])C(C)(C)[C@@H](O[C@H]4CN(C5CN(C(C)C)C5)CCO4)CC[C@@]36C7)([H])[C@@]67CC[C@]2(C)[C@]8([H])[C@@]1([H])O[C@@H]([C@H](OCC)C(C)(O)C)C[C@H]8C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 701.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W. Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts. Medicines (Basel). 2015 Jun 30;2(3):127-140. doi: 10.3390/medicines2030127. Review. PubMed PMID: 28930205; PubMed Central PMCID: PMC5456218. 2: Hubbs JL, Fuller NO, Austin WF, Shen R, Ma J, Gong Z, Li J, McKee TD, Loureiro RM, Tate B, Dumin JA, Ives J, Bronk BS. Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1621-6. doi: 10.1016/j.bmcl.2015.01.051. Epub 2015 Feb 10. PubMed PMID: 25708617. 3: Loureiro RM, Dumin JA, McKee TD, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS, Tate B. Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models. Alzheimers Res Ther. 2013 Apr 18;5(2):19. doi: 10.1186/alzrt173. eCollection 2013. PubMed PMID: 23597079; PubMed Central PMCID: PMC3707052.