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MedKoo Cat#: 564503 | Name: KRN4884

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRN4884 is a potassium channel opener.

Chemical Structure

KRN4884
KRN4884
CAS#152802-84-1

Theoretical Analysis

MedKoo Cat#: 564503

Name: KRN4884

CAS#: 152802-84-1

Chemical Formula: C15H14ClN5

Exact Mass: 299.0938

Molecular Weight: 299.76

Elemental Analysis: C, 60.10; H, 4.71; Cl, 11.83; N, 23.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KRN-4884; KRN 4884; KRN4884
IUPAC/Chemical Name
5-Amino-N'-[2-(2-chlorophenyl)ethyl]-N-cyanopyridine-3-carboximidamide
InChi Key
NDGLGOGSZCDCPI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14ClN5/c16-14-4-2-1-3-11(14)5-6-20-15(21-10-17)12-7-13(18)9-19-8-12/h1-4,7-9H,5-6,18H2,(H,20,21)
SMILES Code
N#CN/C(C1=CC(N)=CN=C1)=N/CCC2=CC=CC=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jewsbury S, Baker PN, Wareing M. Relaxation of human placental arteries and veins by ATP-sensitive potassium channel openers. Eur J Clin Invest. 2007 Jan;37(1):65-72. PubMed PMID: 17181569. 2: Ren Z, Yang Q, Floten HS, He GW. Hypoxic preconditioning in coronary microarteries: role of EDHF and K+ channel openers. Ann Thorac Surg. 2002 Jul;74(1):143-8. PubMed PMID: 12118747. 3: Muraki K, Sasaoka A, Ohya S, Watanabe M, Imaizumi Y. Effects of KRN4884, a novel K+ channel opener, on ionic currents in rabbit femoral arterial myocytes. J Pharmacol Sci. 2003 Nov;93(3):289-98. PubMed PMID: 14646246. 4: Ren Z, Yang Q, Floten HS, Furnary AP, Yim AP, He GW. ATP-sensitive potassium channel openers may mimic the effects of hypoxic preconditioning on the coronary artery. Ann Thorac Surg. 2001 Feb;71(2):642-7. PubMed PMID: 11235721. 5: Ren Z, Floten S, Furnary A, Liu M, Gately H, Swanson J, Ahmad A, Yim AP, He GW. Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts. Br J Clin Pharmacol. 2000 Aug;50(2):154-60. PubMed PMID: 10930967; PubMed Central PMCID: PMC2014397. 6: Okada Y, Yoshino T, Takeuchi A, Endoh M, Ohta H, Jinno Y, Yokoyama T, Izawa T, Kobayshi E. Effects of the K+ channel opener KRN4884 on the cardiovascular metabolic syndrome model in rats. J Cardiovasc Pharmacol. 2000 Feb;35(2):287-93. PubMed PMID: 10672863. 7: Kawahara J, Kashiwabara T, Ogawa N, Okada Y, Izawa T. Antihypertensive properties of KRN4884, a novel long-lasting potassium channel opener. J Cardiovasc Pharmacol. 1999 Feb;33(2):292-4. PubMed PMID: 10028939. 8: Harada K, Kawahara J, Okada Y, Uzumaki H, Kusaka M, Tokiwa T. Effects of KRN4884 (a novel K+ channel opener), levcromakalim, nilvadipine and propranolol on endothelin-1-induced heart disorders in anesthetized rats. Jpn J Pharmacol. 1998 Nov;78(3):261-8. PubMed PMID: 9869259. 9: Yoshino T, Ohta H, Jinno Y, Torii Y, Ogawa N, Izawa T, Okada Y. Protective effect of the K+ channel opener KRN4884 on peripheral occlusive arterial disease in rats. Gen Pharmacol. 1998 Jul;31(1):59-62. PubMed PMID: 9595280. 10: Yokoyama T, Izumi H, Endoh M, Ogawa N, Izawa T, Okada Y. Effect of KRN4884 on lipid metabolism in hyperlipidemic rats. Gen Pharmacol. 1998 Feb;30(2):233-7. PubMed PMID: 9502179.

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