Synonym
TC 2559 (fumarate)
IUPAC/Chemical Name
4-(5-ethoxy-3-pyridinyl)-N-methyl-3-buten-1-amine, difumaric acid
InChi Key
GEWVPSJQGJBDLM-MYBAKCFCSA-N
InChi Code
InChI=1S/C12H18N2O.2C4H4O4/c1-3-15-12-8-11(9-14-10-12)6-4-5-7-13-2;2*5-3(6)1-2-4(7)8/h4,6,8-10,13H,3,5,7H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b6-4+;2*2-1+
SMILES Code
CNCC/C=C/C1=CC(OCC)=CN=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O
Purity
≥95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
438.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Bencherif, M., Bane, A.J., Miller, C.H., et al. TC-2559: A novel orally active ligand selective at neuronal acetylcholine receptors Eur. J. Pharmacol. 409(1), 45-55 (2000).
2. Chen, Y., Sharples, T.J.W., Phillips, K.G., et al. The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices Neuropharmacology 45(3), 334-344 (2003).
3. Cheng, L.-Z., Han, L., Fan, J., et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559 Mol. Pain 7:56, (2011).
