IDF-11774 | CAS#1429054-28-3 | HIF-1inhibitor

MedKoo Cat#: 584683 | Name: IDF-11774

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor.

Chemical Structure

IDF-11774

CAS#1429054-28-3

Theoretical Analysis

MedKoo Cat#: 584683

Name: IDF-11774

CAS#: 1429054-28-3

Chemical Formula: C23H32N2O2

Exact Mass: 368.2464

Molecular Weight: 368.52

Elemental Analysis: C, 74.96; H, 8.75; N, 7.60; O, 8.68

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,750.00	2 Weeks
2g	USD 6,250.00	2 Weeks

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Related CAS #

No Data

Synonym

IDF-11774; IDF 11774; IDF11774

IUPAC/Chemical Name

2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one

InChi Key

QGBBBLPWBSWERZ-KIOFGVERSA-N

InChi Code

InChI=1S/C23H32N2O2/c1-24-6-8-25(9-7-24)22(26)16-27-21-4-2-20(3-5-21)23-13-17-10-18(14-23)12-19(11-17)15-23/h2-5,17-19H,6-16H2,1H3/t17-,18-,19-,23?

SMILES Code

O=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 368.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li Y, Zhu R, He X, Song Y, Fan T, Ma J, Xiang G, Ma X. Discovery of potent hypoxia-inducible factor-1α (HIF-1α) degraders by proteolysis targeting chimera (PROTAC). Bioorg Chem. 2024 Dec;153:107943. doi: 10.1016/j.bioorg.2024.107943. Epub 2024 Nov 4. PMID: 39536629. 2: Cao Y, Chen F, Zhu S, Zhu D, Qi H. Staphylococcus aureus infection initiates hypoxia-mediated STIP1 homology and U-box containing protein 1 upregulation to trigger osteomyelitis. Toxicon. 2024 Sep;248:108049. doi: 10.1016/j.toxicon.2024.108049. Epub 2024 Jul 24. PMID: 39059559. 3: Kim WH, Kim MJ, Jin JO, Lee PCW. IDF-11774 Induces Cell Cycle Arrest and Apoptosis by Inhibiting HIF-1α in Gastric Cancer. Pharmaceutics. 2023 Dec 13;15(12):2772. doi: 10.3390/pharmaceutics15122772. PMID: 38140111; PMCID: PMC10748108. 4: Zhang W, Lin Y, Zong Y, Ma X, Jiang C, Shan H, Xia W, Yin L, Wang N, Zhou L, Zhou Z, Yu X. Staphylococcus aureus Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis. mSystems. 2022 Aug 30;7(4):e0038022. doi: 10.1128/msystems.00380-22. Epub 2022 Jul 19. PMID: 35852344; PMCID: PMC9426532. 5: Kim NH, Jeong JH, Park YJ, Shin HY, Choi WK, Lee K, Lee AY. Anti-Tumor Effect of IDF-11774, an Inhibitor of Hypoxia-Inducible Factor-1, on Melanoma. Biomol Ther (Seoul). 2022 Sep 1;30(5):465-472. doi: 10.4062/biomolther.2022.061. Epub 2022 Jun 17. PMID: 35712870; PMCID: PMC9424330. 6: Shen Z, Pei Q, Zhang H, Yang C, Cui H, Li B, Liu J, Bo Z, Wei F, Zhang M, Liu C. Hypoxia-inducible factor-1α inhibition augments efficacy of programmed cell death 1 antibody in murine prostatic cancer models. Anticancer Drugs. 2022 Jul 1;33(6):587-594. doi: 10.1097/CAD.0000000000001294. Epub 2022 Mar 23. PMID: 35324523. 7: Zheng L, Wang B, Sun Y, Dai B, Fu Y, Zhang Y, Wang Y, Yang Z, Sun Z, Zhuang S, Zhang D. An Oxygen-Concentration-Controllable Multiorgan Microfluidic Platform for Studying Hypoxia-Induced Lung Cancer-Liver Metastasis and Screening Drugs. ACS Sens. 2021 Mar 26;6(3):823-832. doi: 10.1021/acssensors.0c01846. Epub 2021 Mar 3. PMID: 33657793. 8: Kim MH, Lee TH, Lee JS, Lim DJ, Lee PC. Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro. Pharmaceuticals (Basel). 2020 Aug 24;13(9):208. doi: 10.3390/ph13090208. PMID: 32847004; PMCID: PMC7558478. 9: Kim BK, Nam SW, Min BS, Ban HS, Paik S, Lee K, Im JY, Lee Y, Park JT, Kim SY, Kim M, Lee H, Won M. Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer. Br J Cancer. 2018 Nov;119(11):1347-1357. doi: 10.1038/s41416-018-0289-1. Epub 2018 Nov 13. PMID: 30420612; PMCID: PMC6265273. 10: Ban HS, Kim BK, Lee H, Kim HM, Harmalkar D, Nam M, Park SK, Lee K, Park JT, Kim I, Lee K, Hwang GS, Won M. The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. Cell Death Dis. 2017 Jun 1;8(6):e2843. doi: 10.1038/cddis.2017.235. PMID: 28569777; PMCID: PMC5520894. 11: Ban HS, Naik R, Kim HM, Kim BK, Lee H, Kim I, Ahn H, Jang Y, Jang K, Eo Y, Song KB, Lee K, Won M. Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes. Bioconjug Chem. 2016 Aug 17;27(8):1911-20. doi: 10.1021/acs.bioconjchem.6b00305. Epub 2016 Jul 18. PMID: 27386732.