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MedKoo Cat#: 555368 | Name: M-31850

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M-31850 is a β-Hexosaminidase Inhibitor. M-31850 showed activity against the insect β-N-acetyl-D-hexosaminidase OfHex2. M-31850 acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN.

Chemical Structure

M-31850
M-31850
CAS#281224-40-6

Theoretical Analysis

MedKoo Cat#: 555368

Name: M-31850

CAS#: 281224-40-6

Chemical Formula: C28H21N3O4

Exact Mass: 463.1532

Molecular Weight: 463.49

Elemental Analysis: C, 72.56; H, 4.57; N, 9.07; O, 13.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
M-31850; M 31850; M31850;
IUPAC/Chemical Name
2,2'-(azanediylbis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione)
InChi Key
UPLUIYHKSADQOZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H21N3O4/c32-25-19-9-1-5-17-6-2-10-20(23(17)19)26(33)30(25)15-13-29-14-16-31-27(34)21-11-3-7-18-8-4-12-22(24(18)21)28(31)35/h1-12,29H,13-16H2
SMILES Code
O=C(C1=CC=CC2=C1C3=CC=C2)N(CCNCCN(C4=O)C(C5=CC=CC6=C5C4=CC=C6)=O)C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The GH20 β-N-acetyl-d-hexosaminidase OfHex2 from the insect Ostrinia furnacalis (Guenée) is a target potential for eco-friendly pesticide development. Although carbohydrate-based inhibitors against β-N-acetyl-D-hexosaminidases are widely studied, highly efficient, non-carbohydrate inhibitors are more attractive due to low cost and readily synthetic manner.

Preparing Stock Solutions

The following data is based on the product molecular weight 463.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu T, Guo P, Zhou Y, Wang J, Chen L, Yang H, Qian X, Yang Q. A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs. Sci Rep. 2014 Aug 26;4:6188. doi: 10.1038/srep06188. PubMed PMID: 25155420; PubMed Central PMCID: PMC4143770. 2: Chen Q, Guo P, Xu L, Liu T, Qian X, Yang Q. Exploring unsymmetrical dyads as efficient inhibitors against the insect β-N-acetyl-D-hexosaminidase OfHex2. Biochimie. 2014 Feb;97:152-62. doi: 10.1016/j.biochi.2013.10.008. Epub 2013 Oct 17. PubMed PMID: 24140956.