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MedKoo Cat#: 564475 | Name: Simfibrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Simfibrate is a peroxisome proliferator.

Chemical Structure

Simfibrate
Simfibrate
CAS#14929-11-4

Theoretical Analysis

MedKoo Cat#: 564475

Name: Simfibrate

CAS#: 14929-11-4

Chemical Formula: C23H26Cl2O6

Exact Mass: 468.1106

Molecular Weight: 469.36

Elemental Analysis: C, 58.86; H, 5.58; Cl, 15.11; O, 20.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cholesolvin; CLY503; CLY-503; CLY 503; Simfibrate
IUPAC/Chemical Name
Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate)
InChi Key
JLRNKCZRCMIVKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3
SMILES Code
CC(C)(OC1=CC=C(Cl)C=C1)C(OCCCOC(C(C)(OC2=CC=C(Cl)C=C2)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takagi A, Sai K, Umemura T, Hasegawa R, Kurokawa Y. Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate. Cancer Lett. 1990 Aug;53(1):33-8. PubMed PMID: 2397479. 2: Kurokawa Y, Takamura N, Matushima Y, Imazawa T, Hayashi Y. Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis. Cancer Lett. 1988 Dec 1;43(1-2):145-9. PubMed PMID: 3203323. 3: Watanabe T, Suga T. Studies on peroxisomes. IX. Biochemical effects of simfibrate on precursor incorporation into polypeptide associated with peroxisome proliferation in rat liver. J Biochem. 1980 Jun;87(6):1595-601. PubMed PMID: 7400111. 4: Cavallini L, Lucchetti G, Marchi S, Guglielmini R. [Action of simfibrate on post-heparin lipoprotein lipase]. Clin Ter. 1980 Jan 15;92(1):25-31. Italian. PubMed PMID: 7004746. 5: Teoh PC, Ransome GA. Primary type V hyperlipoproteinaemia (mixed hyperlipaemia): successful response to dietary restriction and simfibrate. Singapore Med J. 1974 Jun;15(2):149-52. PubMed PMID: 4370285.