MedKoo Cat#: 564472 | Name: TAS-303

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAS-303 is a selective norepinephrine reuptake inhibitor which displays significant norepinephrine transporter (NET) inhibitory activity toward serotonin or dopamine transporters. Radioligand-binding studies showed that TAS-303 selectively and potently inhibited [3H]norepinephrine binding to the human NET.

Chemical Structure

TAS-303
TAS-303
CAS#1449371-87-2 (D7),

Theoretical Analysis

MedKoo Cat#: 564472

Name: TAS-303

CAS#: 1449371-87-2 (D7),

Chemical Formula: C22H20D7NO3

Exact Mass: 360.2430

Molecular Weight: 360.50

Elemental Analysis: C, 73.30; H, 9.50; N, 3.89; O, 13.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
108640-65-9 (H7) 1449371-87-2 (D7) 1449371-86-1 (D5) 1449371-94-1 (D7 HCl) 1449371-93-0 (D5 HCl)
Synonym
TAS 303; TAS303; TAS-303
IUPAC/Chemical Name
Piperidin-4-yl 2,2-diphenyl-2-(propoxy-d7)acetate
InChi Key
FMRVAGKPRZLTRG-KORWVGAPSA-N
InChi Code
InChI=1S/C22H27NO3/c1-2-17-25-22(18-9-5-3-6-10-18,19-11-7-4-8-12-19)21(24)26-20-13-15-23-16-14-20/h3-12,20,23H,2,13-17H2,1H3/i1D3,2D2,17D2
SMILES Code
O=C(OC1CCNCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mizutani H, Sakakibara F, Komuro M, Sasaki E. TAS-303, a Novel Selective Norepinephrine Reuptake Inhibitor that Increases Urethral Pressure in Rats, Indicating Its Potential as a Therapeutic Agent for Stress Urinary Incontinence. J Pharmacol Exp Ther. 2018 Aug;366(2):322-331. doi: 10.1124/jpet.118.248039. Epub 2018 Jun 6. PubMed PMID: 29875227.